Add to ORKGSeveral hypothetical bone remodeling models have been developed to explain trabecular bone adaptation as observed in the skeleton. So far, these simulation models have been successfully used to explain the global density distribution in whole bones but were unable to simulate trabecular adaptation process at the tissue level. In the presented study, a three dimensional bone remodeling model is introduced to simulate bone remodeling at the tissue level. The model is based on an osteocyte regulated bone remodeling hypothesis. The trabecular architecture is represented by large FE models built from identical elements to allow the application of fast solution methods. It was found that the model can explain the generation of typical three dimen...