Heart failure with preserved ejection fraction (HFpEF) is a complex heterogeneous disease for which our pathophysiological understanding is still limited and specific prevention and treatment strategies are lacking. HFpEF is characterised by diastolic dysfunction and cardiac remodelling (fibrosis, inflammation, and hypertrophy). Recently, microvascular dysfunction and chronic low-grade inflammation have been proposed to participate in HFpEF development. Furthermore, several recent studies demonstrated the occurrence of generalized lymphatic dysfunction in experimental models of risk factors for HFpEF, including obesity, hypercholesterolaemia, type 2 diabetes mellitus (T2DM), hypertension, and aging. Here, we review the evidence for a combin...
OBJECTIVES: The present study investigated whether systemic, low-grade inflammation of metabolic ris...
Many patients with symptoms and signs of heart failure have a left ventricular ejection fraction ≥50...
Item does not contain fulltextHeart failure with preserved ejection fraction (HFpEF) is highly preva...
Heart failure with preserved ejection fraction (HFpEF) is a complex heterogeneous disease for which ...
Heart failure with preserved ejection fraction (HFpEF) is an increasingly studied entity accounting ...
Heart failure with preserved ejection fraction (HFpEF) is a condition with increasing incidence, lea...
Heart failure with preserved ejection fraction (HFpEF) is one of the greatest unmet needs in modern ...
Over the past decade, myocardial structure, cardiomyocyte function, and intramyocardial signaling we...
Heart failure with preserved ejection fraction (HFpEF) has been recognized as the greatest single un...
Heart failure with preserved ejection fraction (HFpEF) is an emerging disease with signs of nonresol...
Heart failure with preserved ejection fraction (HFpEF) currently accounts for approximately half of ...
Heart failure with preserved ejection fraction (HFpEF) is increasing in prevalence worldwide, alread...
Heart failure with preserved ejection fraction (HFpEF) currently accounts for approximately half of ...
Heart failure with preserved ejection fraction (HFpEF) is increasing in prevalence worldwide, alread...
OBJECTIVES: The present study investigated whether systemic, low-grade inflammation of metabolic ris...
Many patients with symptoms and signs of heart failure have a left ventricular ejection fraction ≥50...
Item does not contain fulltextHeart failure with preserved ejection fraction (HFpEF) is highly preva...
Heart failure with preserved ejection fraction (HFpEF) is a complex heterogeneous disease for which ...
Heart failure with preserved ejection fraction (HFpEF) is an increasingly studied entity accounting ...
Heart failure with preserved ejection fraction (HFpEF) is a condition with increasing incidence, lea...
Heart failure with preserved ejection fraction (HFpEF) is one of the greatest unmet needs in modern ...
Over the past decade, myocardial structure, cardiomyocyte function, and intramyocardial signaling we...
Heart failure with preserved ejection fraction (HFpEF) has been recognized as the greatest single un...
Heart failure with preserved ejection fraction (HFpEF) is an emerging disease with signs of nonresol...
Heart failure with preserved ejection fraction (HFpEF) currently accounts for approximately half of ...
Heart failure with preserved ejection fraction (HFpEF) is increasing in prevalence worldwide, alread...
Heart failure with preserved ejection fraction (HFpEF) currently accounts for approximately half of ...
Heart failure with preserved ejection fraction (HFpEF) is increasing in prevalence worldwide, alread...
OBJECTIVES: The present study investigated whether systemic, low-grade inflammation of metabolic ris...
Many patients with symptoms and signs of heart failure have a left ventricular ejection fraction ≥50...
Item does not contain fulltextHeart failure with preserved ejection fraction (HFpEF) is highly preva...