White matter hyperintensities in vascular contributions to cognitive impairment and dementia (VCID):Knowledge gaps and opportunities
- Alber, Jessica
- Alladi, Suvarna
- Bae, Hee-Joon
- Barton, David A
- Beckett, Laurel A
- Bell, Joanne M
- Berman, Sara E
- Biessels, Geert Jan
- Black, Sandra E
- Bos, Isabelle
- Bowman, Gene L
- Brai, Emanuele
- Brickman, Adam M
- Callahan, Brandy L
- Corriveau, Roderick A
- Fossati, Silvia
- Gottesman, Rebecca F
- Gustafson, Deborah R
- Hachinski, Vladimir
- Hayden, Kathleen M
- Helman, Alex M
- Hughes, Timothy M
- Isaacs, Jeremy D
- Jefferson, Angela L
- Johnson, Sterling C
- Kapasi, Alifiya
- Kern, Silke
- Kwon, Jay C
- Kukolja, Juraj
- Lee, Athene
- Lockhart, Samuel N
- Murray, Anne
- Osborn, Katie E
- Power, Melinda C
- Price, Brittani R
- Rhodius-Meester, Hanneke F M
- Rondeau, Jacqueline A
- Rosen, Allyson C
- Rosene, Douglas L
- Schneider, Julie A
- Scholtzova, Henrieta
- Shaaban, C Elizabeth
- Silva, Narlon C B S
- Snyder, Heather M
- Swardfager, Walter
- Troen, Aron M
- van Veluw, Susanne J
- Vemuri, Prashanthi
- Wallin, Anders
- Wellington, Cheryl
- Wilcock, Donna M
- Xie, Sharon Xiangwen
- Hainsworth, Atticus H
DOIAbstract
White matter hyperintensities (WMHs) are frequently seen on brain magnetic resonance imaging scans of older people. Usually interpreted clinically as a surrogate for cerebral small vessel disease, WMHs are associated with increased likelihood of cognitive impairment and dementia (including Alzheimer's disease [AD]). WMHs are also seen in cognitively healthy people. In this collaboration of academic, clinical, and pharmaceutical industry perspectives, we identify outstanding questions about WMHs and their relation to cognition, dementia, and AD. What molecular and cellular changes underlie WMHs? What are the neuropathological correlates of WMHs? To what extent are demyelination and inflammation present? Is it helpful to subdivide into perive...
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