Bone has an intrinsic healing capacity that may be exceeded when the fracture gap is too big or unstable. In that moment, osteogenic measures need to be taken by physicians. It is important to combine cells, scaffolds and growth factors, and the correct mechanical conditions. Growth factors are clinically administered as recombinant proteins. They are, however, expensive and needed in high supraphysiological doses. Moreover, their half-life is short when administered to the fracture. Therefore, gene therapy may be an alternative. Cells can constantly produce the protein of interest in the correct folding, with the physiological glycosylation and in the needed amounts. Genes can be delivered in vivo or ex vivo by viral or non-viral methods. ...
Vascularization and bone repair are accelerated by a series of gene-activated scaffolds delivering b...
Bone tissue loss as a consequence of the natural aging process or as a result of trauma and degenera...
© 2016, Springer Science+Business Media New York.Though normally bone regenerates well, non-union, d...
Bone has an intrinsic healing capacity that may be exceeded when the fracture gap is too big or unst...
Gene therapy provides a promising approach for regeneration and repair of injured bone. Application ...
Gene therapy has developed during the last two decades as a promising strategy for orthopaedics appl...
Although gene therapy has its conceptual origins in the treatment of Mendelian disorders, it has pot...
Craniofacial anomalies, bone defects and cartilage lesions pose a difficult and challenging problem ...
Gene therapy holds a great promise and has been extensively investigated to improve bone formation a...
Abstract: Efficacious bone regeneration could revolutionize the clinical management of many bone and...
Recent advances in tissue engineering have made progress towards the development of biomaterials cap...
Recent advances in tissue engineering have made progress toward the development of biomaterials capa...
Although gene therapy has its conceptual origins in the treatment of Mendelian disorders, it has pot...
Recent advances in the approval and commercialization of gene therapeutics have fostered the return ...
Varied clinical problems have created a need to repair and regenerate bone. Tissue engineering is an...
Vascularization and bone repair are accelerated by a series of gene-activated scaffolds delivering b...
Bone tissue loss as a consequence of the natural aging process or as a result of trauma and degenera...
© 2016, Springer Science+Business Media New York.Though normally bone regenerates well, non-union, d...
Bone has an intrinsic healing capacity that may be exceeded when the fracture gap is too big or unst...
Gene therapy provides a promising approach for regeneration and repair of injured bone. Application ...
Gene therapy has developed during the last two decades as a promising strategy for orthopaedics appl...
Although gene therapy has its conceptual origins in the treatment of Mendelian disorders, it has pot...
Craniofacial anomalies, bone defects and cartilage lesions pose a difficult and challenging problem ...
Gene therapy holds a great promise and has been extensively investigated to improve bone formation a...
Abstract: Efficacious bone regeneration could revolutionize the clinical management of many bone and...
Recent advances in tissue engineering have made progress towards the development of biomaterials cap...
Recent advances in tissue engineering have made progress toward the development of biomaterials capa...
Although gene therapy has its conceptual origins in the treatment of Mendelian disorders, it has pot...
Recent advances in the approval and commercialization of gene therapeutics have fostered the return ...
Varied clinical problems have created a need to repair and regenerate bone. Tissue engineering is an...
Vascularization and bone repair are accelerated by a series of gene-activated scaffolds delivering b...
Bone tissue loss as a consequence of the natural aging process or as a result of trauma and degenera...
© 2016, Springer Science+Business Media New York.Though normally bone regenerates well, non-union, d...