Background: Amyloid pathology is the pathological hallmark in Alzheimer's disease (AD) and can precede clinical dementia by decades. So far it remains unclear how amyloid pathology leads to cognitive impairment and dementia. To design AD prevention trials it is key to include cognitively normal subjects at high risk for amyloid pathology and to find predictors of cognitive decline in these subjects. These goals can be accomplished by targeting twins, with additional benefits to identify genetic and environmental pathways for amyloid pathology, other AD biomarkers, and cognitive decline. Methods: From December 2014 to October 2017 we enrolled cognitively normal participants aged 60 years and older from the ongoing Manchester and Newcastle Ag...
IMPORTANCE: Cerebral amyloid-beta aggregation is an early pathological event in Alzheimer disease (A...
Background: Similar to most chronic diseases, Alzheimer's disease (AD) develops slowly from a precli...
© 2013 Dr. Yen Ying LimAlzheimer’s disease (AD) is pathologically characterised by neurofibrillary t...
Background: Amyloid pathology is the pathological hallmark in Alzheimer's disease (AD) and can prece...
Background: Amyloid pathology is the pathological hallmark in Alzheimer's disease (AD) and can prece...
Background: Amyloid pathology is the pathological hallmark in Alzheimer's disease (AD) and can prece...
Importance: One characteristic histopathological event in Alzheimer disease (AD) is cerebral amyloid...
Importance: One characteristic histopathological event in Alzheimer disease (AD) is cerebral amyloid...
Importance: National Institute on Aging-Alzheimer's Association (NIA-AA) workgroups have proposed bi...
International audienceBackground: Identifying comorbidities that influence preclinical Alzheimer’s d...
Background: There is an urgent need for novel, noninvasive biomarkers to diagnose Alzheimer's diseas...
Amyloid pathology in cognitively normal older adults has been associated with low memory performance...
Amyloid pathology in cognitively normal older adults has been associated with low memory performance...
Introduction: We aimed to examine the contribution of subjective cognitive decline (SCD) to reduce t...
IMPORTANCE: Cerebral amyloid-beta aggregation is an early pathological event in Alzheimer disease (A...
Background: Similar to most chronic diseases, Alzheimer's disease (AD) develops slowly from a precli...
© 2013 Dr. Yen Ying LimAlzheimer’s disease (AD) is pathologically characterised by neurofibrillary t...
Background: Amyloid pathology is the pathological hallmark in Alzheimer's disease (AD) and can prece...
Background: Amyloid pathology is the pathological hallmark in Alzheimer's disease (AD) and can prece...
Background: Amyloid pathology is the pathological hallmark in Alzheimer's disease (AD) and can prece...
Importance: One characteristic histopathological event in Alzheimer disease (AD) is cerebral amyloid...
Importance: One characteristic histopathological event in Alzheimer disease (AD) is cerebral amyloid...
Importance: National Institute on Aging-Alzheimer's Association (NIA-AA) workgroups have proposed bi...
International audienceBackground: Identifying comorbidities that influence preclinical Alzheimer’s d...
Background: There is an urgent need for novel, noninvasive biomarkers to diagnose Alzheimer's diseas...
Amyloid pathology in cognitively normal older adults has been associated with low memory performance...
Amyloid pathology in cognitively normal older adults has been associated with low memory performance...
Introduction: We aimed to examine the contribution of subjective cognitive decline (SCD) to reduce t...
IMPORTANCE: Cerebral amyloid-beta aggregation is an early pathological event in Alzheimer disease (A...
Background: Similar to most chronic diseases, Alzheimer's disease (AD) develops slowly from a precli...
© 2013 Dr. Yen Ying LimAlzheimer’s disease (AD) is pathologically characterised by neurofibrillary t...