Predictors for poor cosmetic outcome in patients with early stage breast cancer treated with breast conserving therapy:Results of the Young boost trial

Purpose: In the Young Boost trial (YBT), breast cancer patientsMethods: From 2004 to 2011, 2421 cT1-2N0-2a breast cancer patients were randomized. CO was scored subjectively by the patient and physician, and objectively using BCCT.core: at baseline, one and four years after treatment. Associations between potential risk factors for worse cosmetic outcome, based on the objective BCCT. core, were investigated using a proportional odds model.Results: At four years, CO was significantly better in the standard boost group for all three scoring methods (satisfied CO +/- 65% vs 55%). A photon boost, high boost dose, poor cosmesis before radiation therapy, large boost volume and adjuvant chemotherapy significantly deteriorated CO.Conclusion: Important risk factors for worse CO were the use of a photon boost instead of an electron boost, a high boost dose, cosmesis at baseline, adjuvant chemotherapy and boost volume. These results can be used to define strategies aimed at improving CO. (C) 2018 Elsevier B.V. All rights reserved.