The prothrombin time/international normalized ratio (PT/INR) Line: derivation of local INR with commercial thromboplastins and coagulometers - two independent studies
- Poller, L.
- Ibrahim, S.
- Keown, M.
- Pattison, A.
- Jespersen, J.
- Marun, S.
- Muntean, W.
- Aspoeck, Gerold
- Gallus, Alex S.
- Bailleul, E.
- Wijns, William
- Michel, T.
- Jochmans, Kristin
- Chatelain, B.
- Marcelis, Carlo L. M.
- Nijs de, A.S.
- Johnston, M.
- Kynde, K.
- Syrjala, M.
- Savolainen, E.-R.
- Ivaska, K.
- Rajamaki, A.
- Vanharanta, R.
- Juhan, I.
- Aillaud, M.-F.
- Guillin, M.-C.
- Huisse, M.-G.
- Sie, P.
- Lecompte, T.
- Schmitt, Y.
- Harenberg, J.
- Plesch, W.
- Aronis, S.
- Theodossiades, George
- Tsoukanas, B.
- Markala, D.
- Ditsa, M.
- Cahill, M.
- Madden, M.
- White, B.
- Nolan, B.T.
- Fitzgerald, H.
- McCarthy, D.
- Collins, B.
- Rooney, S.
- Naparstek, E.
- Palareti, G.
- Marongiu, F.
- Erba, N.
- Testa, Sophie
- Mariani, G.
- Poti, R.
- Mannucci, P. M.
- Tripodi, A.
- Bader, R.
- Pengo, Vittorio
- Gresele, Paolo
- D'inca, Marco
- Ageno, W.
- Tosetto, Alberto
- Hensgens, H. E. S. J.
- Idema, R. N.
- Oosterhout, D. H.
- Mulder, A. B.
- Hamulyak, K.
- van der Dussen, H.
- Musial, J.
- Gago, T.
- Palmeiro, A.
- Campos, Manuel
- Marques-Dias, D. A.
- Monteiro, A. Cunha
- Cunha, M. Angela
- de Gaia, W. N.
- Peternel, P.
- Stegnar, M.
- Fontcuberta, J.
- Borrell, M.
- Reverter, J. C.
- Santasusana, P. Domenech
- Lopez-Fernandez, M. Fernanda
- Castro-Montero, José Luis
- Ribera Casado, C.
- Vicente, Vicente
- Edlund, B.
- Egberg, N.
- Laemmle, B.
- Alberio, L.
- de Moerloose, P.
- Reber, G.
- Machin, S. J.
- Mackie, I.
- Lawrie, A.
- Luckit, J.
- Shanks, D.
- Dolan, G.
- Flaherty, T.
- Ludlam, C. A.
- Walker, I. D.
- Lawson, D. E.
- Triscott, M.
- Marlar, R. A.
- Heit, J. A.
- Watzke, H.
- Weisser, B.
- Osmond, J.
- Cornet, I.
- Munster, A.-M.
- Leed, B.
- Chillou, C.
- Defard, M.
- Horellou, M. H.
- Halkin, H.
- Loebstein, R.
- Kirgner, I.
- Dentali, F.
- Trapani Lombardo, V.
- Sottilotta, Gianluca
- Consiglio, P.
- De Michele, S.
- Moia, M.
- Carpenedo, Monica
- Manotti, C.
- Tassoni, M. Ilaria
- Cosmi, B.
- Brusi, C.
- Legnani, C.
- Pegoraro, C.
- Andriani, C.
- Grazia Cirigliano, M.
- Ribaldi, E.
- Abbate, R.
- Poli, D.
- Perricone, C.
- Schiavuli, M.
- Casiera, C.
- Lupone, M. R.
- Rossi, Emanuela
- Crivelli, S.
- Birolini, A.
- Parente, F.
- Miglietta, A. M.
- Campobasso, M.
- Sydor, W.
- Krevel, B.
- Fernandez, T. M. A.
- Lozano, Andres M.
- Shiach, C.
- Bowyer, C.
- Charles, F.
DOIAbstract
The WHO scheme for prothrombin time (PT) standardization has been limited in application, because of its difficulties in implementation, particularly the need for mandatory manual PT testing and for local provision of thromboplastin international reference preparations (IRP).The value of a new simpler procedure to derive international normalized ratio (INR), the PT/INR Line, based on only five European Concerted Action on Anticoagulation (ECAA) calibrant plasmas certified by experienced centres has been assessed in two independent exercises using a range of commercial thromboplastins and coagulometers. INRs were compared with manual certified values with thromboplastin IRP from expert centres and in the second study also with INRs from loca...
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