BACKGROUND CONTEXT: Sciatica is a condition characterized by radicular pain that can be secondary to a lumbar disc herniation (LDH). More than 10% of patients report persistent pain after surgery. The underlying mechanisms of postoperative sciatica remain unclear. There is evidence demonstrating that inflammation plays a role in the pathophysiology of sciatica. PURPOSE: The study aimed to assess if the expression of tumor necrosis factor (TNF)-alpha and its receptors (TNFR) was correlated with the severity of pre- and postoperative leg pain in LDH patients who underwent single or multiple decompressive discectomies. SETTING: This is an experimental prospective human study of intraoperative intervertebral disc (IVD) samples, as well as a cli...
International audienceIntroductionThe aim of this study was to assess the efficacy and safety of tum...
INTRODUCTION: Spontaneous resorption of disc herniation (DH) after sciatica is well documented. The ...
Inflammation plays a key role in the development of sensitization after peripheral nerve damage. We ...
BACKGROUND CONTEXT: Sciatica is a condition characterized by radicular pain that can be secondary to...
Lumbar disc hernia (LDH) is a leading cause of chronic pain in adults. The underlying pathology of c...
BACKGROUND: The pathophysiology of pain in patients with symptomatic thoracic disc herniation (TDH) ...
STUDY DESIGN: Case-control study. OBJECTIVE: To determine whether inflammatory cytokines [tumor necr...
Previous experimental models have shown that proinflammatory cytokines modulate peripheral and centr...
Background: Lumbar disc herniation is often associated with an inflammatory process. In this context...
Study DesignCohort study.PurposeThis study primarily aimed to evaluate the serum levels of tumor nec...
ntroduction: The cause of low back pain and the pathophysiology of lumbar pain and sciatica have rec...
CONTEXT AND OBJECTIVE: The role of immune response and proinflammatory cytokines in the pathogenesis...
Herniation of the lumbar disc can cause severe pain radiating down the leg alongside a dermatome. Th...
Purpose: To study the interaction between Modic changes (MC) and inflammation by macrophages in the ...
ObjectiveTo assess the efficacy and safety of tumor necrosis factor (TNF)-α inhibition with inflixim...
International audienceIntroductionThe aim of this study was to assess the efficacy and safety of tum...
INTRODUCTION: Spontaneous resorption of disc herniation (DH) after sciatica is well documented. The ...
Inflammation plays a key role in the development of sensitization after peripheral nerve damage. We ...
BACKGROUND CONTEXT: Sciatica is a condition characterized by radicular pain that can be secondary to...
Lumbar disc hernia (LDH) is a leading cause of chronic pain in adults. The underlying pathology of c...
BACKGROUND: The pathophysiology of pain in patients with symptomatic thoracic disc herniation (TDH) ...
STUDY DESIGN: Case-control study. OBJECTIVE: To determine whether inflammatory cytokines [tumor necr...
Previous experimental models have shown that proinflammatory cytokines modulate peripheral and centr...
Background: Lumbar disc herniation is often associated with an inflammatory process. In this context...
Study DesignCohort study.PurposeThis study primarily aimed to evaluate the serum levels of tumor nec...
ntroduction: The cause of low back pain and the pathophysiology of lumbar pain and sciatica have rec...
CONTEXT AND OBJECTIVE: The role of immune response and proinflammatory cytokines in the pathogenesis...
Herniation of the lumbar disc can cause severe pain radiating down the leg alongside a dermatome. Th...
Purpose: To study the interaction between Modic changes (MC) and inflammation by macrophages in the ...
ObjectiveTo assess the efficacy and safety of tumor necrosis factor (TNF)-α inhibition with inflixim...
International audienceIntroductionThe aim of this study was to assess the efficacy and safety of tum...
INTRODUCTION: Spontaneous resorption of disc herniation (DH) after sciatica is well documented. The ...
Inflammation plays a key role in the development of sensitization after peripheral nerve damage. We ...