Physical activity attenuates the effect of the FTO genotype on obesity traits in European adults: The Food4Me study
- Celis-Morales, Carlos
- Marsaux, Cyril F. M.
- Livingstone, Katherine M.
- Navas-Carretero, Santiago
- San-Cristobal, Rodrigo
- O'donovan, Clare B.
- Forster, Hannah
- Woolhead, Clara
- Fallaize, Rosalind
- Macready, Anna L.
- Kolossa, Silvia
- Hallmann, Jacqueline
- Tsirigoti, Lydia
- Lambrinou, Christina P.
- Moschonis, George
- Godlewska, Magdalena
- Surwillo, Agnieszka
- Grimaldi, Keith
- Bouwman, Jildau
- Manios, Yannis
- Traczyk, Iwona
- Drevon, Christian A.
- Parnell, Laurence D.
- Daniel, Hannelore
- Gibney, Eileen R.
- Brennan, Lorraine
- Walsh, Marianne C.
- Gibney, Mike
- Lovegrove, Julie A.
- Alfredo Martinez, J.
- Saris, Wim H. M.
- Mathers, John C.
Publication date
April 2016
DOIAbstract
Objective To examine whether the effect of FTO loci on obesity-related traits could be modified by physical activity (PA) levels in European adults. MethodsOf 1,607 Food4Me participants randomized, 1,280 were genotyped for FTO (rs9939609) and had available PA data. PA was measured objectively using accelerometers (TracmorD, Philips), whereas anthropometric measures [BMI and waist circumference (WC)] were self-reported via the Internet. ResultsFTO genotype was associated with a higher body weight [: 1.09 kg per risk allele, (95% CI: 0.14-2.04), P=0.024], BMI [: 0.54 kgm(-2), (0.23-0.83),
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