Creeping Proteins in Microporous Structures: Polymer Brush-Assisted Fabrication of 3D Gradients for Tissue Engineering
- Gunnewiek, Michel Klein
- Di Luca, Andrea
- Bollemaat, Hermannes Z.
- van Blitterswijk, Clemens A.
- Vancso, G. Julius
- Moroni, Lorenzo
- Benetti, Edmondo M.
DOIAbstract
Coupling of rapid prototyping techniques and surface-confined polymerizations allows the fabrication of 3D multidirectional gradients of biomolecules within microporous scaffolds. The compositional gradients can be tailored by polymer-brush-assisted diffusion of protein solutions. This technique allows spatial control over stem cells manipulation within 3D environments. ? 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
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