Multi-level biomarker analysis of nitric oxide synthase isoforms in bipolar disorder and adult ADHD

Kittel-Schneider, Sarah
Reuss, Martin
Meyer, Andrea
Weber, Heike
Gessner, Alexandra
Leistner, Carolin
Kopf, Juliane
Schmidt, Brigitte
Hempel, Susanne
Volkert, Julia
Lesch, Klaus-Peter
Reif, Andreas

Publication date

January 2015

DOI

Abstract

Several studies have shown altered levels of nitric oxide (NO) and its stable metabolites (NOx (-)) in blood and cerebrospinal fluid of psychiatric patients. The aim of our study was to replicate previous findings and investigate the influence of the nitrinergic system in bipolar disorder and adult attention-deficit/hyperactivity disorder (aADHD) in particular.The concentrations of NO2 (-) and NO3 (-) in peripheral blood in a sample of aADHD, bipolar disorder (BPD) and controls were analysed. The sample was genotyped for a three marker haplotype in the NOS3 gene (rs2070744, rs1799983 and Intron 4 VNTR) and for genetic variants of the NOS1 gene (NOS1 ex 1c, NOS1 ex 1f). Finally, qRT PCR was performed.We found significantly lower NOx (-) leve...