A Randomized Trial of Intraarterial Treatment for Acute Ischemic Stroke
- Berkhemer, O. A.
- Fransen, P. S. S.
- Beumer, D.
- van den Berg, L. A.
- Lingsma, H. F.
- Yoo, A. J.
- Schonewille, W. J.
- Vos, J. A.
- Nederkoorn, P. J.
- Wermer, M. J. H.
- van Walderveen, M. A. A.
- Staals, J.
- Hofmeijer, J.
- van Oostayen, J. A.
- Nijeholt, G. J. Lycklama A.
- Boiten, J.
- Brouwer, P. A.
- Emmer, B. J.
- de Bruijn, S. F.
- van Dijk, L. C.
- Kappelle, L. J.
- Lo, R. H.
- Van Dijk, E. J.
- de Vries, J.
- de Kort, P. L. M.
- van Rooij, W. J. J.
- van den Berg, J. S. P.
- van Hasselt, B. A. A. M.
- Aerden, L. A. M.
- Dallinga, R. J.
- Visser, M. C.
- Bot, J. C. J.
- Vroomen, P. C.
- Eshghi, O.
- Schreuder, T. H. C. M. L.
- Heijboer, R. J. J.
- Keizer, K.
- Tielbeek, A. V.
- den Hertog, H. M.
- Gerrits, D. G.
- van den Berg-Vos, R. M.
- Karas, G. B.
- Steyerberg, E. W.
- Flach, H. Z.
- Marquering, H. A.
- Sprengers, M. E. S.
- Jenniskens, S. F. M.
- Beenen, L. F. M.
- van den Berg, R.
- Koudstaal, P. J.
- van Zwam, W. H.
- Roos, Y. B. W. E. M.
- van der Lugt, A.
- van Oostenbrugge, R. J.
- Majoie, C. B. L. M.
- Dippel, D. W. J.
DOIAbstract
BACKGROUND In patients with acute ischemic stroke caused by a proximal intracranial arterial occlusion, intraarterial treatment is highly effective for emergency revascularization. However, proof of a beneficial effect on functional outcome is lacking. METHODS We randomly assigned eligible patients to either intraarterial treatment plus usual care or usual care alone. Eligible patients had a proximal arterial occlusion in the anterior cerebral circulation that was confirmed on vessel imaging and that could be treated intraarterially within 6 hours after symptom onset. The primary outcome was the modified Rankin scale score at 90 days; this categorical scale measures functional outcome, with scores ranging from 0 (no symptoms) to 6 (death). ...
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