Mutations in the A-type lamins A and C, two major components of the nuclear lamina, cause a large group of phenotypically diverse diseases collectively referred to as laminopathies. These conditions often involve defects in chromatin organization. However, it is unclear whether A-type lamins interact with chromatin in vivo and whether aberrant chromatin-lamin interactions contribute to disease. Here, we have used an unbiased approach to comparatively map genome-wide interactions of gene promoters with lamin A and progerin, the mutated lamin A isoform responsible for the premature aging disorder Hutchinson-Gilford progeria syndrome (HGPS) in mouse cardiac myoytes and embryonic fibroblasts. We find that lamin A-associated genes are predominan...
Session 2: Systemic signals and stem cellsAbnormal splicing of LMNA gene gives rise to a truncated p...
The nuclear lamina contributes to the regulation of gene expression and to chromatin organization. M...
Hutchinson-Gilford progeria syndrome (HGPS) is a rare human genetic disease that leads to premature ...
Mutations in the A-type lamins A and C, two major components of the nuclear lamina, cause a large gr...
components of the nuclear lamina, cause a large group of phenotypically diverse diseases collectivel...
The Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic disorder caused by a mutation in t...
Hutchinson-Gilford progeria syndrome (HGPS) is a rare human genetic disease that leads to premature ...
Progeroid laminopathies are characterized by the premature appearance of certain signs of physiologi...
Hutchinson-Gilford progeria syndrome (HGPS) is a premature aging disease that is frequently caused b...
Lamin A and lamin C (A-type lamins, both encoded by the LMNA gene) are major components of the mamma...
AbstractMutations in the lamin A/C (LMNA) gene that cause Hutchinson-Gilford progeria syndrome (HGPS...
Hutchinson-Gilford progeria syndrome (HGPS) is a genetic disorder displaying features reminiscent of...
Premature aging syndromes often result from mutations in nuclear proteins involved in the maintenanc...
Premature aging syndromes often result from mutations in nuclear proteins involved in the maintenanc...
Hutchinson-Gilford progeria syndrome (HGPS) is a rare disease with a striking phenotype---children w...
Session 2: Systemic signals and stem cellsAbnormal splicing of LMNA gene gives rise to a truncated p...
The nuclear lamina contributes to the regulation of gene expression and to chromatin organization. M...
Hutchinson-Gilford progeria syndrome (HGPS) is a rare human genetic disease that leads to premature ...
Mutations in the A-type lamins A and C, two major components of the nuclear lamina, cause a large gr...
components of the nuclear lamina, cause a large group of phenotypically diverse diseases collectivel...
The Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic disorder caused by a mutation in t...
Hutchinson-Gilford progeria syndrome (HGPS) is a rare human genetic disease that leads to premature ...
Progeroid laminopathies are characterized by the premature appearance of certain signs of physiologi...
Hutchinson-Gilford progeria syndrome (HGPS) is a premature aging disease that is frequently caused b...
Lamin A and lamin C (A-type lamins, both encoded by the LMNA gene) are major components of the mamma...
AbstractMutations in the lamin A/C (LMNA) gene that cause Hutchinson-Gilford progeria syndrome (HGPS...
Hutchinson-Gilford progeria syndrome (HGPS) is a genetic disorder displaying features reminiscent of...
Premature aging syndromes often result from mutations in nuclear proteins involved in the maintenanc...
Premature aging syndromes often result from mutations in nuclear proteins involved in the maintenanc...
Hutchinson-Gilford progeria syndrome (HGPS) is a rare disease with a striking phenotype---children w...
Session 2: Systemic signals and stem cellsAbnormal splicing of LMNA gene gives rise to a truncated p...
The nuclear lamina contributes to the regulation of gene expression and to chromatin organization. M...
Hutchinson-Gilford progeria syndrome (HGPS) is a rare human genetic disease that leads to premature ...