Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus
- Hanssen, M.J.
- Hoeks, J.
- Brans, B.
- van der Lans, A.A.
- Schaart, G.
- van den Driessche, J.J.
- Jorgensen, J.A.
- Boekschoten, M.V.
- Hesselink, M.K.
- Havekes, B.
- Kersten, S.
- Mottaghy, F.M.
- van Marken Lichtenbelt, W.D.
- Schrauwen, P.
DOIAbstract
Cold exposure may be a potential therapy for diabetes by increasing brown adipose tissue (BAT) mass and activity. Here we report that 10 d of cold acclimation (14-15 degrees C) increased peripheral insulin sensitivity by approximately 43% in eight type 2 diabetes subjects. Basal skeletal muscle GLUT4 translocation markedly increased, without effects on insulin signaling or AMP-activated protein kinase (AMPK) activation and only a minor increase in BAT glucose uptake
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