Elucidating the underlying mechanisms of inflammation caused by perinatal asphyxia and chorioamnionitis

Perinatal asphyxia and chorioamnionitis are both important neonatal complications that can lead to serious organ disorders and even neonatal death. This dissertation studied the underlying mechanisms of inflammation in these complications to reach new insights and treatment therapies. An important connection was shown between the production of cytokines, ceramides and the occurrence of cell death after foetal asphyxia. This interaction can play an important role in neuroprotection. Furthermore the research has shown that prenatal complications such as chorioamniotitis can lead to liver inflammation with disorders in the lipid metabolism as a consequence.