Multiple Negative Fecal Immunochemical Tests Reduce Risk of Advanced Neoplasia in a Colonoscopy Surveillance Program
- Wassie, M.M.
- Young, G.P.
- Winter, J.M.
- Cock, C.
- Bampton, P.
- Rahman, M.
- Heddle, R.
- Fraser, R.
- Meng, R.
- Symonds, E.L.
DOIAbstract
OnlinePublBackground & Aims: In above-average-risk individuals undergoing colonoscopy-based surveillance for colorectal cancer (CRC), screening with fecal immunochemical tests (FIT) between colonoscopies might facilitate personalization of surveillance intervals. Because a negative FIT is associated with a reduced risk for CRC, we examined the relationship between number of rounds of negative FIT and risk for advanced neoplasia in individuals undergoing surveillance colonoscopy. Methods: We conducted a retrospective cohort study on 4021 surveillance intervals in 3369 individuals (50–74 years), who had completed a 2-sample FIT between colonoscopies, from 1 to 4 rounds at 1–2 yearly intervals, each with a negative result (<20 mg hemoglobin/g ...
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