During stress, eukaryotes regulate protein synthesis in part through formation of cytoplasmic, non-membrane-bound complexes called stress granules (SGs). SGs transiently store signaling proteins and stalled translational complexes in response to stress stimuli (e.g. oxidative insult, DNA damage, temperature shifts and ER dysfunction). The functional outcome of SGs is proper translational regulation and signaling, allowing cells to overcome stress. The fatal motor neuron disease Amyotrophic Lateral Sclerosis (ALS) develops in an age-related manner and is marked by progressive neuronal death, with cytoplasmic protein aggregation, excitotoxicity and increased oxidative stress as major hallmarks. Fused in Sarcoma/Translocated in Liposarcoma (FU...
Mutations in Fused-in-Sarcoma (FUS) gene involving the nuclear localization signal (NLS) domain lead...
Both protein and RNA quality control are critical for cell survival during stress and are disrupted ...
Mutations in the RNA-binding protein FUS (fused in sarcoma) are linked to amyotrophic lateral sclero...
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by pref...
Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease is a fatal neurodegenerative...
Formation of cytoplasmic RNA-protein structures called stress granules (SGs) is a highly conserved c...
BACKGROUND: Amyotrophic lateral sclerosis (ALS)-linked fused in sarcoma/translocated in liposarcoma ...
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the death ...
Stress granules (SGs) are cytoplasmic ribonucleoprotein aggregates which form in response to cellula...
Summary: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder causing progressive los...
Amyotrophic lateral sclerosis (ALS) is a fatal human neurodegenerative disease affecting primarily m...
Articulo de publicación SCOPUSMutations in fused in sarcoma and/or translocated in liposarcoma (FUS,...
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by motor neur...
Patient-derived induced Pluripotent Stem Cells (iPSCs) provide an opportunity to study human disease...
Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease characterized by the preferential...
Mutations in Fused-in-Sarcoma (FUS) gene involving the nuclear localization signal (NLS) domain lead...
Both protein and RNA quality control are critical for cell survival during stress and are disrupted ...
Mutations in the RNA-binding protein FUS (fused in sarcoma) are linked to amyotrophic lateral sclero...
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by pref...
Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease is a fatal neurodegenerative...
Formation of cytoplasmic RNA-protein structures called stress granules (SGs) is a highly conserved c...
BACKGROUND: Amyotrophic lateral sclerosis (ALS)-linked fused in sarcoma/translocated in liposarcoma ...
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the death ...
Stress granules (SGs) are cytoplasmic ribonucleoprotein aggregates which form in response to cellula...
Summary: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder causing progressive los...
Amyotrophic lateral sclerosis (ALS) is a fatal human neurodegenerative disease affecting primarily m...
Articulo de publicación SCOPUSMutations in fused in sarcoma and/or translocated in liposarcoma (FUS,...
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by motor neur...
Patient-derived induced Pluripotent Stem Cells (iPSCs) provide an opportunity to study human disease...
Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease characterized by the preferential...
Mutations in Fused-in-Sarcoma (FUS) gene involving the nuclear localization signal (NLS) domain lead...
Both protein and RNA quality control are critical for cell survival during stress and are disrupted ...
Mutations in the RNA-binding protein FUS (fused in sarcoma) are linked to amyotrophic lateral sclero...