This study proposes to directly test the hypothesis that antibody-dependent enhancement (ADE) is the critical factor in the development of dengue hemorrhagic fever (DHF) in infants. DHF occurs in two distinct clinical settings: a) in children and adults with secondary DENV infection, and b) in infants with primary DENV infection born to mothers with prior DENV infection. The ADE hypothesis proposes that pre-existing serotype-cross-reactive non-neutralizing anti-DENV antibodies bind the heterotypic DENV during secondary infection and enhance its uptake into immune cells, leading to increased viral load and DHF. This model suggests that DHF in DENV-infected infants is caused by the enhancing effect of waning maternal anti-DENV antibodies, thu...
Dengue hemorrhagic fever can occur in primary dengue virus (DENV) infection of infants. The decay of...
Difficulties inherent in the identification of immune correlates of protection or severe disease hav...
The pathogenesis of dengue in infants is poorly understood. We postulated that dengue severity in in...
BACKGROUND: Dengue hemorrhagic fever (DHF) is the severe and life-threatening syndrome that can deve...
This study proposes to directly test the hypothesis that antibody-dependent enhancement (ADE) is the...
Background: Dengue hemorrhagic fever (DHF) is the severe and life-threatening syndrome that can deve...
Dengue hemorrhagic fever (DHF) is the severe and life-threatening syndrome that can develop after in...
Dengue, a mosquito-borne viral illness caused by dengue virus types (DENV)-1 to DENV-4, is endemic i...
International audienceTo understand the role of maternal dengue-specific antibodies in the developme...
Dengue virus (DENV) infections range from asymptomatic or mild illness to a severe and potentially l...
<div><p>Dengue (DEN) represents the most serious arthropod-borne viral disease. DEN clinical manifes...
BACKGROUND: Infants born to dengue immune mothers acquire maternal antibodies to dengue. These antib...
Dengue hemorrhagic fever can occur in primary dengue virus (DENV) infection of infants. The decay o...
Dengue (DEN) represents the most serious arthropod-borne viral disease. DEN clinical manifestations ...
Antibody (Ab)-dependent enhancement can exacerbate dengue virus (DENV) infection due to cross-reacti...
Dengue hemorrhagic fever can occur in primary dengue virus (DENV) infection of infants. The decay of...
Difficulties inherent in the identification of immune correlates of protection or severe disease hav...
The pathogenesis of dengue in infants is poorly understood. We postulated that dengue severity in in...
BACKGROUND: Dengue hemorrhagic fever (DHF) is the severe and life-threatening syndrome that can deve...
This study proposes to directly test the hypothesis that antibody-dependent enhancement (ADE) is the...
Background: Dengue hemorrhagic fever (DHF) is the severe and life-threatening syndrome that can deve...
Dengue hemorrhagic fever (DHF) is the severe and life-threatening syndrome that can develop after in...
Dengue, a mosquito-borne viral illness caused by dengue virus types (DENV)-1 to DENV-4, is endemic i...
International audienceTo understand the role of maternal dengue-specific antibodies in the developme...
Dengue virus (DENV) infections range from asymptomatic or mild illness to a severe and potentially l...
<div><p>Dengue (DEN) represents the most serious arthropod-borne viral disease. DEN clinical manifes...
BACKGROUND: Infants born to dengue immune mothers acquire maternal antibodies to dengue. These antib...
Dengue hemorrhagic fever can occur in primary dengue virus (DENV) infection of infants. The decay o...
Dengue (DEN) represents the most serious arthropod-borne viral disease. DEN clinical manifestations ...
Antibody (Ab)-dependent enhancement can exacerbate dengue virus (DENV) infection due to cross-reacti...
Dengue hemorrhagic fever can occur in primary dengue virus (DENV) infection of infants. The decay of...
Difficulties inherent in the identification of immune correlates of protection or severe disease hav...
The pathogenesis of dengue in infants is poorly understood. We postulated that dengue severity in in...