Add to ORKGCoronary vessel development is a crucial part of heart development requiring the interplay of the epicardial, myocardial and endocardial layers of the heart for proper formation. Coronary vascularization is regulated by a host of transcription factors further regulated by chromatin remodeling enzymes, including Histone Deacetylases (HDACs). To investigate the functions of HDACs in coronary vascular development, we have deleted Hdac3 in endocardial cells using Cre LoxP technology. Endocardial cell-‐specific deletion of Hdac3 results in aberrant coronary vessel formation and complete postnatal lethality. We have thus shown that Hdac3 is a critical regulator of the coronary vascular development pathway
Organismal physiology is built upon the foundation of molecular processes. A central axis to maintai...
Tissue-specific progenitor cells emerge during development to expand and differentiate into the mult...
Vertebrate embryogenesis relies on the coordinated development of multiple progenitor cell pools. Sp...
Disruptions in cardiac development cause congenital heart disease, the most prevalent and deadly con...
HDACs can modify the structure and function of chromatin to regulate gene expression and can also mo...
Tissue-specific progenitor cells emerge during development to expand and differentiate into the mult...
Vertebrate embryogenesis relies on the coordinated development of multiple progenitor cell pools. Sp...
Background: Histone deacetylase 3 (HDAC3) is known to play a crucial role in the differentiation of ...
Background-Histone deacetylase 3 (HDAC3) is known to play a crucial role in the differentiation of e...
HDACs can modify the structure and function of chromatin to regulate gene expression and can also mo...
Background/Aims: Histone deacetylases (HDACs) play a critical role in the regulation of gene transcr...
Mammalian gene expression is activated by histone acetylation, which is reversed by histone deacetyl...
Macrophages are key immune cells found in atherosclerotic plaques and critically shape atherosclerot...
Angiogenesis requires the coordinated growth and migration of endothelial cells (ECs), with each EC ...
Histone deacetylase (HDAC) inhibition plays a crucial role in mediating cardiogenesis and myocardial...
Organismal physiology is built upon the foundation of molecular processes. A central axis to maintai...
Tissue-specific progenitor cells emerge during development to expand and differentiate into the mult...
Vertebrate embryogenesis relies on the coordinated development of multiple progenitor cell pools. Sp...
Disruptions in cardiac development cause congenital heart disease, the most prevalent and deadly con...
HDACs can modify the structure and function of chromatin to regulate gene expression and can also mo...
Tissue-specific progenitor cells emerge during development to expand and differentiate into the mult...
Vertebrate embryogenesis relies on the coordinated development of multiple progenitor cell pools. Sp...
Background: Histone deacetylase 3 (HDAC3) is known to play a crucial role in the differentiation of ...
Background-Histone deacetylase 3 (HDAC3) is known to play a crucial role in the differentiation of e...
HDACs can modify the structure and function of chromatin to regulate gene expression and can also mo...
Background/Aims: Histone deacetylases (HDACs) play a critical role in the regulation of gene transcr...
Mammalian gene expression is activated by histone acetylation, which is reversed by histone deacetyl...
Macrophages are key immune cells found in atherosclerotic plaques and critically shape atherosclerot...
Angiogenesis requires the coordinated growth and migration of endothelial cells (ECs), with each EC ...
Histone deacetylase (HDAC) inhibition plays a crucial role in mediating cardiogenesis and myocardial...
Organismal physiology is built upon the foundation of molecular processes. A central axis to maintai...
Tissue-specific progenitor cells emerge during development to expand and differentiate into the mult...
Vertebrate embryogenesis relies on the coordinated development of multiple progenitor cell pools. Sp...