We have previously shown that the keys to high-level nontoxic chimerism in syngeneic models are stem cell toxic, nonmyelotoxic host treatment as provided by 100-cGy whole-body irradiation and relatively high levels of marrow stem cells. This approach was unsuccessful in H-2 mismatched B6.SJL to BALB/c marrow transplants, but with tolerization, stable multilineage chimerism was obtained. Ten million B6.SJL spleen cells were infused intravenously into BALB/c hosts on day -10 and (MR-1) anti-CD40 ligand monoclonal antibody (mAb) injected intraperitoneally at varying levels on days -10, -7, -3, 0, and +3 and the BALB/c mice irradiated (100 cGy) and infused with 40 million B6.SJL/H-2 mismatched marrow cells on day 0. Stable multilineage chimeris...
AbstractGene therapy, the replacement of normal human beta- or gamma-globin genes into the hematopoi...
SummaryIn this study, we demonstrate a newly derived mouse model that supports engraftment of human ...
Item does not contain fulltextPatients who are receiving an organ transplant nowadays are sentenced ...
We describe a tolerance-based stem cell transplantation protocol that combines sublethal radiation w...
Graft rejection and graft-versus-host disease are major problems in mismatched marrow transplants al...
AbstractMixed hematopoietic chimerism can be induced in mice receiving allogeneic bone marrow transp...
Studies on mixed chimerism are currently focused primarily on obtaining less toxic conditioning prot...
Mixed chimerism and tolerance can be successfully induced in rodents through allogeneic bone marrow ...
AbstractMixed lymphohematopoietic chimerism can be induced in mice with bone marrow transplantation ...
PubMed ID: 16339691Stable mixed chimeric stem cell transplantation in hemoglobinopathies exploits sh...
WOS: 000187122000059PubMed ID: 12933586Bone marrow transplantation (BMT) is the only curative therap...
Allogeneic hematopoietic chimerism leading to central tolerance has significant therapeutic potentia...
Abstract Background: We previously demonstrated that a high level of chimerism was induced by low do...
Although stable mixed-hematopoietic chimerism induces robust immune tolerance to solid organ allogra...
AbstractTraditional approaches to allogeneic stem cell transplantation have relied on the use of tox...
AbstractGene therapy, the replacement of normal human beta- or gamma-globin genes into the hematopoi...
SummaryIn this study, we demonstrate a newly derived mouse model that supports engraftment of human ...
Item does not contain fulltextPatients who are receiving an organ transplant nowadays are sentenced ...
We describe a tolerance-based stem cell transplantation protocol that combines sublethal radiation w...
Graft rejection and graft-versus-host disease are major problems in mismatched marrow transplants al...
AbstractMixed hematopoietic chimerism can be induced in mice receiving allogeneic bone marrow transp...
Studies on mixed chimerism are currently focused primarily on obtaining less toxic conditioning prot...
Mixed chimerism and tolerance can be successfully induced in rodents through allogeneic bone marrow ...
AbstractMixed lymphohematopoietic chimerism can be induced in mice with bone marrow transplantation ...
PubMed ID: 16339691Stable mixed chimeric stem cell transplantation in hemoglobinopathies exploits sh...
WOS: 000187122000059PubMed ID: 12933586Bone marrow transplantation (BMT) is the only curative therap...
Allogeneic hematopoietic chimerism leading to central tolerance has significant therapeutic potentia...
Abstract Background: We previously demonstrated that a high level of chimerism was induced by low do...
Although stable mixed-hematopoietic chimerism induces robust immune tolerance to solid organ allogra...
AbstractTraditional approaches to allogeneic stem cell transplantation have relied on the use of tox...
AbstractGene therapy, the replacement of normal human beta- or gamma-globin genes into the hematopoi...
SummaryIn this study, we demonstrate a newly derived mouse model that supports engraftment of human ...
Item does not contain fulltextPatients who are receiving an organ transplant nowadays are sentenced ...