AIM: To investigate plasma microRNA (miRNA) profiles indicative of hepatotoxicity in the setting of lethal acetaminophen (APAP) toxicity in mice. METHODS: Using plasma from APAP poisoned mice, either lethally (500 mg/kg) or sublethally (150 mg/kg) dosed, we screened commercially available murine microRNA libraries (SABiosciences, Qiagen Sciences, MD) to evaluate for unique miRNA profiles between these two dosing parameters. RESULTS: We distinguished numerous, unique plasma miRNAs both up- and downregulated in lethally compared to sublethally dosed mice. Of note, many of the greatest up- and downregulated miRNAs, namely 574-5 p, 466 g, 466 f-3p, 375, 29 c, and 148 a, have been shown to be associated with asthma in prior studies. Interestingl...
Introduction and objectives: N-acetyl-p-aminophenol (APAP)-induced liver injury is a major clinical ...
Context: New biomarkers are needed in acetaminophen (APAP) hepatotoxicity. Plasma argininosuccinate ...
Adverse effects caused by therapeutic drugs are a serious and costly health concern. Despite the bod...
Background To investigate plasma microRNA (miRNA) profiles indicative of hepatotoxicity in the sett...
INTRODUCTION: Acetaminophen toxicity has been associated with elevation of microRNAs. The present st...
Our objective was to identify microRNA (miRNA) biomarkers of drug-induced liver and kidney injury by...
AbstractDeveloping biomarkers for detecting acetaminophen (APAP) toxicity has been widely investigat...
Objective: Unusual clinical courseBackground: Acetaminophen overdose is the most common cause of acu...
We have identified, by quantitative real-time PCR, hundreds of miRNAs that are dramatically elevated...
Acetaminophen is the primary cause of acute liver toxicity in Europe/USA, which led the FDA to recon...
Acetaminophen is the primary cause of acute liver toxicity in Europe/USA, which led the FDA to recon...
Acetaminophen is the most used analgesic and anti-pyretic drug in the world, but also one of the mai...
Administration of high doses of acetaminophen (APAP) is known to cause drug-induced liver injury (DI...
Gene expression profiling is a widely used technique with data from the majority of published microa...
After over 60 years of therapeutic use in the UK, paracetamol (acetaminophen, N-acetyl-p-aminophenol...
Introduction and objectives: N-acetyl-p-aminophenol (APAP)-induced liver injury is a major clinical ...
Context: New biomarkers are needed in acetaminophen (APAP) hepatotoxicity. Plasma argininosuccinate ...
Adverse effects caused by therapeutic drugs are a serious and costly health concern. Despite the bod...
Background To investigate plasma microRNA (miRNA) profiles indicative of hepatotoxicity in the sett...
INTRODUCTION: Acetaminophen toxicity has been associated with elevation of microRNAs. The present st...
Our objective was to identify microRNA (miRNA) biomarkers of drug-induced liver and kidney injury by...
AbstractDeveloping biomarkers for detecting acetaminophen (APAP) toxicity has been widely investigat...
Objective: Unusual clinical courseBackground: Acetaminophen overdose is the most common cause of acu...
We have identified, by quantitative real-time PCR, hundreds of miRNAs that are dramatically elevated...
Acetaminophen is the primary cause of acute liver toxicity in Europe/USA, which led the FDA to recon...
Acetaminophen is the primary cause of acute liver toxicity in Europe/USA, which led the FDA to recon...
Acetaminophen is the most used analgesic and anti-pyretic drug in the world, but also one of the mai...
Administration of high doses of acetaminophen (APAP) is known to cause drug-induced liver injury (DI...
Gene expression profiling is a widely used technique with data from the majority of published microa...
After over 60 years of therapeutic use in the UK, paracetamol (acetaminophen, N-acetyl-p-aminophenol...
Introduction and objectives: N-acetyl-p-aminophenol (APAP)-induced liver injury is a major clinical ...
Context: New biomarkers are needed in acetaminophen (APAP) hepatotoxicity. Plasma argininosuccinate ...
Adverse effects caused by therapeutic drugs are a serious and costly health concern. Despite the bod...