Recurrent chromosomal translocations can drive oncogenesis, but how they form has remained elusive. Now, Chiarle et al. (2011) and Klein et al. (2011) characterize the genome-wide spectrum of translocations that form from a single double-stranded break, revealing that specific loci have an intrinsic predisposition for frequent chromosomal rearrangements
Abstract Background Gene rearrangements such as chromosomal translocations have been shown to contri...
Recurrent chromosomal translocations underlie both haematopoietic and solid tumours. Their origin ha...
Chromosomal translocations are one of the most common types of genetic rearrangements and are molecu...
Recurrent chromosomal translocations can drive oncogenesis, but how they form has remained elusive. ...
SummaryWhereas chromosomal translocations are common pathogenetic events in cancer, mechanisms that ...
SummaryChromosomal rearrangements, including translocations, require formation and joining of DNA do...
<div><p>Chromosomal translocations are frequent features of cancer genomes that contribute to diseas...
Chromosomal translocations are frequent features of cancer genomes that contribute to disease progre...
Chromosomal translocations require formation and joining of DNA double strand breaks (DSBs). These e...
Chromosomal translocations drive the development of many hematological and some solid cancers. Sever...
Chromosomal translocations drive the development of many hematological and some solid cancers. Sever...
Abstract: We show that introns harboring translocation breakpoints in tumors are significantly longe...
Chromosomal translocations arising from aberrant repair of multiple DNA double-strand breaks (DSBs) ...
In classical models of tumorigenesis, the accumulation of tumor promoting chromosomal aberrations is...
Chromosomal rearrangements occur as a consequence of the erroneous repair of DNA double-stranded bre...
Abstract Background Gene rearrangements such as chromosomal translocations have been shown to contri...
Recurrent chromosomal translocations underlie both haematopoietic and solid tumours. Their origin ha...
Chromosomal translocations are one of the most common types of genetic rearrangements and are molecu...
Recurrent chromosomal translocations can drive oncogenesis, but how they form has remained elusive. ...
SummaryWhereas chromosomal translocations are common pathogenetic events in cancer, mechanisms that ...
SummaryChromosomal rearrangements, including translocations, require formation and joining of DNA do...
<div><p>Chromosomal translocations are frequent features of cancer genomes that contribute to diseas...
Chromosomal translocations are frequent features of cancer genomes that contribute to disease progre...
Chromosomal translocations require formation and joining of DNA double strand breaks (DSBs). These e...
Chromosomal translocations drive the development of many hematological and some solid cancers. Sever...
Chromosomal translocations drive the development of many hematological and some solid cancers. Sever...
Abstract: We show that introns harboring translocation breakpoints in tumors are significantly longe...
Chromosomal translocations arising from aberrant repair of multiple DNA double-strand breaks (DSBs) ...
In classical models of tumorigenesis, the accumulation of tumor promoting chromosomal aberrations is...
Chromosomal rearrangements occur as a consequence of the erroneous repair of DNA double-stranded bre...
Abstract Background Gene rearrangements such as chromosomal translocations have been shown to contri...
Recurrent chromosomal translocations underlie both haematopoietic and solid tumours. Their origin ha...
Chromosomal translocations are one of the most common types of genetic rearrangements and are molecu...
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