Clinical trials are under way using fetal cells to repair damaged neuronal circuitry. However, little is known about how transplanted immature neurons can grow anatomically correct connections in the adult central nervous system (CNS). We transplanted embryonic porcine neural cells in vivo into adult rat brains with neuronal and axonal loss typical of Parkinson\u27s or Huntington\u27s disease. Using complementary species-specific cellular markers, we found donor axons and CD44+ astroglial fibres in host white matter tracts up to 8 mm from CNS transplant sites, although only donor axons were capable of reaching correct gray matter target regions. This work demonstrates that adult host brain can orient growth of transplanted neurons and that ...
Transplants of cells and tissues to the central nervous system of adult mammals can, under appropria...
The success of transplants of neural tissue into the adult dentate gyrus in generating mature neuron...
Neurotransplantation of human fetal dopamine (DA) neurons is currently being investigated as a thera...
Primary neural cells do not appear to migrate significantly following transplantation into the adult...
Transplantation of embryonic or stem cell derived neurons has been proposed as a potential therapy f...
Neural progenitor cell (NPC) transplantation has high therapeutic potential in neurological disorder...
International audienceInjury to the human central nervous system can lead to devastating consequence...
Neural precursors with the properties of neural stem cells can be isolated from the developing brain...
Recently in Nature Neuroscience, Gaillard et al. (2007) study axonal projections from embryonic cort...
One obstacle with grafting of dopamine neurons in Parkinson's disease is the insufficient ability of...
Progenitor cells were isolated from the developing human central nervous system (CNS), induced to di...
Reconstruction of CNS circuitry is a major aim of neural transplantation, and is currently being ass...
The mature mammalian central nervous system (CNS) is unable to regenerate successfully after injury....
Intracerebral neuronal transplantation have been shown to ameliorate symptoms of brain dysfunction i...
Effective treatments for degenerative and traumatic diseases of the nervous system are not currently...
Transplants of cells and tissues to the central nervous system of adult mammals can, under appropria...
The success of transplants of neural tissue into the adult dentate gyrus in generating mature neuron...
Neurotransplantation of human fetal dopamine (DA) neurons is currently being investigated as a thera...
Primary neural cells do not appear to migrate significantly following transplantation into the adult...
Transplantation of embryonic or stem cell derived neurons has been proposed as a potential therapy f...
Neural progenitor cell (NPC) transplantation has high therapeutic potential in neurological disorder...
International audienceInjury to the human central nervous system can lead to devastating consequence...
Neural precursors with the properties of neural stem cells can be isolated from the developing brain...
Recently in Nature Neuroscience, Gaillard et al. (2007) study axonal projections from embryonic cort...
One obstacle with grafting of dopamine neurons in Parkinson's disease is the insufficient ability of...
Progenitor cells were isolated from the developing human central nervous system (CNS), induced to di...
Reconstruction of CNS circuitry is a major aim of neural transplantation, and is currently being ass...
The mature mammalian central nervous system (CNS) is unable to regenerate successfully after injury....
Intracerebral neuronal transplantation have been shown to ameliorate symptoms of brain dysfunction i...
Effective treatments for degenerative and traumatic diseases of the nervous system are not currently...
Transplants of cells and tissues to the central nervous system of adult mammals can, under appropria...
The success of transplants of neural tissue into the adult dentate gyrus in generating mature neuron...
Neurotransplantation of human fetal dopamine (DA) neurons is currently being investigated as a thera...