Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive motor neuron degeneration, paralysis, and death. Mutant Cu,Zn-superoxide dismutase (SOD1) causes a subset of ALS by an unidentified toxic property. Increasing evidence suggests that chaperone dysfunction plays a role in motor neuron degeneration in ALS. To investigate the relationship between mutant SOD1 expression and chaperone dysfunction, we measured chaperone function in central nervous system tissue lysates from normal mice and transgenic mice expressing human SOD1 variants. We observed a significant decrease in chaperone activity in tissues from mice expressing ALS-linked mutant SOD1 but not control mice expressing human wild type SOD1. Thi...
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the loss ...
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the loss ...
Familial amyotrophic lateral sclerosis (FALS) is caused, in 20 % of cases, by mutations in the Cu/Zn...
AbstractOne cause of amyotrophic lateral sclerosis (ALS) is mutation in ubiquitously expressed coppe...
Amyotrophic lateral sclerosis (ALS) is characterized by the progressive loss of upper and lower moto...
Mutations of human Cu,Zn superoxide dismutase (SOD) are found in about 20 percent of patients with f...
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the selec...
AbstractMutations in Cu/Zn superoxide dismutase (SOD1) cause a subset of cases of familial amyotroph...
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the loss ...
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the loss ...
Amyotrophic lateral sclerosis (ALS) is a late onset neuro-degenerative disorder characterized by hig...
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the loss ...
The mechanisms by which mutations in the gene encoding superoxide dismutase 1 (S0D1) lead to amyotro...
Familial amyotrophic lateral sclerosis (FALS) is caused, in 20 % of cases, by mutations in the Cu/Zn...
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the loss ...
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the loss ...
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the loss ...
Familial amyotrophic lateral sclerosis (FALS) is caused, in 20 % of cases, by mutations in the Cu/Zn...
AbstractOne cause of amyotrophic lateral sclerosis (ALS) is mutation in ubiquitously expressed coppe...
Amyotrophic lateral sclerosis (ALS) is characterized by the progressive loss of upper and lower moto...
Mutations of human Cu,Zn superoxide dismutase (SOD) are found in about 20 percent of patients with f...
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the selec...
AbstractMutations in Cu/Zn superoxide dismutase (SOD1) cause a subset of cases of familial amyotroph...
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the loss ...
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the loss ...
Amyotrophic lateral sclerosis (ALS) is a late onset neuro-degenerative disorder characterized by hig...
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the loss ...
The mechanisms by which mutations in the gene encoding superoxide dismutase 1 (S0D1) lead to amyotro...
Familial amyotrophic lateral sclerosis (FALS) is caused, in 20 % of cases, by mutations in the Cu/Zn...
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the loss ...
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the loss ...
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the loss ...
Familial amyotrophic lateral sclerosis (FALS) is caused, in 20 % of cases, by mutations in the Cu/Zn...