Upon recognition of microbial products, Toll-like receptors (TLRs) recruit distinct combinations of adaptors to induce TLR-specific gene expression. In this issue, Kagan and Medzhitov (2006) demonstrate that the adaptor TIRAP/Mal localizes to the plasma membrane by binding to phosphatidylinositol 4,5-bisphosphate (PIP2). This binding recruits a key adaptor MyD88 to TLR4, suggesting that there is crosstalk between the TLR signaling pathway and phospholipid metabolism
During an infection, one of the principal challenges for the host is to detect the pathogen and acti...
Initiation of the innate immune response requires agonist recognition by pathogen-recognition recept...
Toll-like receptors (TLRs) are transmembrane proteins acting mainly as sensors of microbial componen...
Upon recognition of microbial products, Toll-like receptors (TLRs) recruit distinct combinations of ...
SummaryToll-like receptors (TLRs) play a critical role in the immune system as sensors of microbial ...
The toll/interleukin 1 receptor (TIR) domain-containing adaptor protein (TIRAP) plays an important r...
In response to microbial or environmental danger signals, represented by structural motifs not nor...
Toll like receptors (TLRs) are important pattern recognition receptors that can detect pathogen and ...
Toll-like receptor (TLR)-4 is a pattern recognition receptor (PRR) that recognises the pathogen-asso...
Toll like receptors (TLRs) are important pattern recognition receptors that can detect pathogen and ...
two adaptor proteins, MyD88 adaptor-like (Mal) and Toll/IL-1 receptor (TIR) domain-containing adapto...
Toll-like receptors (TLRs) have been established to play an essential role in the activation of inna...
In response to microbial or environmental “danger ” signals, represented by structural motifsnot nor...
The recognition of microbial pathogens by the innate immune system involves Toll-like receptors (TLR...
Toll-like receptor (TLR) family members recognize specific molecular patterns within pathogens. Sign...
During an infection, one of the principal challenges for the host is to detect the pathogen and acti...
Initiation of the innate immune response requires agonist recognition by pathogen-recognition recept...
Toll-like receptors (TLRs) are transmembrane proteins acting mainly as sensors of microbial componen...
Upon recognition of microbial products, Toll-like receptors (TLRs) recruit distinct combinations of ...
SummaryToll-like receptors (TLRs) play a critical role in the immune system as sensors of microbial ...
The toll/interleukin 1 receptor (TIR) domain-containing adaptor protein (TIRAP) plays an important r...
In response to microbial or environmental danger signals, represented by structural motifs not nor...
Toll like receptors (TLRs) are important pattern recognition receptors that can detect pathogen and ...
Toll-like receptor (TLR)-4 is a pattern recognition receptor (PRR) that recognises the pathogen-asso...
Toll like receptors (TLRs) are important pattern recognition receptors that can detect pathogen and ...
two adaptor proteins, MyD88 adaptor-like (Mal) and Toll/IL-1 receptor (TIR) domain-containing adapto...
Toll-like receptors (TLRs) have been established to play an essential role in the activation of inna...
In response to microbial or environmental “danger ” signals, represented by structural motifsnot nor...
The recognition of microbial pathogens by the innate immune system involves Toll-like receptors (TLR...
Toll-like receptor (TLR) family members recognize specific molecular patterns within pathogens. Sign...
During an infection, one of the principal challenges for the host is to detect the pathogen and acti...
Initiation of the innate immune response requires agonist recognition by pathogen-recognition recept...
Toll-like receptors (TLRs) are transmembrane proteins acting mainly as sensors of microbial componen...