Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression
- Stein, Gary S.
- Lian, Jane B.
- Van Wijnen, Andre J.
- Stein, Janet L.
- Montecino, Martin A.
- Javed, Amjad
- Zaidi, Sayyed K.
- Young, Daniel W.
- Choi, Je-Yong
- Pockwinse, Shirwin M.
Publication date
May 2004
DOI Publisher
Springer Science and Business Media LLC ISSN
0950-9232 Citation count (estimate)
315Abstract
We present an overview of Runx involvement in regulatory mechanisms that are requisite for fidelity of bone cell growth and differentiation, as well as for skeletal homeostasis and the structural and functional integrity of skeletal tissue. Runx-mediated control is addressed from the perspective of support for biological parameters of skeletal gene expression. We review recent findings that are consistent with an active role for Runx proteins as scaffolds for integration, organization and combinatorial assembly of nucleic acids and regulatory factors within the three-dimensional context of nuclear architecture
Add to ORKG