Characterization of regulatory sequences and their cognate binding factors in the bone-specific osteocalcin (OC) gene promoter has provided insight into mechanisms that control expression of the gene under diverse biological conditions. We present evidence for AP-1 motifs and two multipartite conserved regulatory sequences, the OC Box I (nt-99 to-76) and a site designated OC Box II (nt-136 to-130) in contributing to developmental and tissue-specific expression of osteocalcin. OC Box I is characterized by a homeodomain binding site and OC Box II is a recognition sequence for AML-1 (also called PEBP2 alpha), a runt homology-related DNA binding protein. Functional activity of the elements was established in osseous and non-osseous cell lines a...
Tissue and cell-type specific expression of the rat osteocalcin (rOC) gene involves the interplay of...
Tissue-specific activation of the osteocalcin (OC) gene is associated with changes in chromatin stru...
Elucidation of molecular mechanisms controlling differentiation and function of osteoblasts is one o...
Bone-specific expression of the osteocalcin gene is transcriptionally controlled. Deletion analysis ...
The OC box of the rat osteocalcin promoter (nt -99 to -76) is the principal proximal regulatory elem...
The bone tissue-specific osteocalcin gene remains one of a few genes that exhibits osteoblast-restri...
Osteocalcin is a 6 kD tissue-specific calcium binding protein associated with the bone extracellular...
Osteocalcin (OC) is a bone specific protein expressed during differentiation and mineralization of t...
Contributing to bone-specific expression of the osteocalcin gene is the promoter element OC Box I (-...
Influences of promoter regulatory elements that are responsive to basal and tissue-restricted transa...
The rat osteocalcin gene encodes a 6-kD osteoblast-specific protein that is expressed post-prolifera...
Activation of tissue-specific genes is a tightly controlled process that normally involves the combi...
Developmental control of bone tissue-specific genes requires positive and negative regulatory factor...
Osteocalcin (OC) is a bone-specific vitamin D- responsive protein that is developmentally expressed ...
Osteocalcin, a bone-specific protein and marker of the mature osteoblast, is expressed only in nonpr...
Tissue and cell-type specific expression of the rat osteocalcin (rOC) gene involves the interplay of...
Tissue-specific activation of the osteocalcin (OC) gene is associated with changes in chromatin stru...
Elucidation of molecular mechanisms controlling differentiation and function of osteoblasts is one o...
Bone-specific expression of the osteocalcin gene is transcriptionally controlled. Deletion analysis ...
The OC box of the rat osteocalcin promoter (nt -99 to -76) is the principal proximal regulatory elem...
The bone tissue-specific osteocalcin gene remains one of a few genes that exhibits osteoblast-restri...
Osteocalcin is a 6 kD tissue-specific calcium binding protein associated with the bone extracellular...
Osteocalcin (OC) is a bone specific protein expressed during differentiation and mineralization of t...
Contributing to bone-specific expression of the osteocalcin gene is the promoter element OC Box I (-...
Influences of promoter regulatory elements that are responsive to basal and tissue-restricted transa...
The rat osteocalcin gene encodes a 6-kD osteoblast-specific protein that is expressed post-prolifera...
Activation of tissue-specific genes is a tightly controlled process that normally involves the combi...
Developmental control of bone tissue-specific genes requires positive and negative regulatory factor...
Osteocalcin (OC) is a bone-specific vitamin D- responsive protein that is developmentally expressed ...
Osteocalcin, a bone-specific protein and marker of the mature osteoblast, is expressed only in nonpr...
Tissue and cell-type specific expression of the rat osteocalcin (rOC) gene involves the interplay of...
Tissue-specific activation of the osteocalcin (OC) gene is associated with changes in chromatin stru...
Elucidation of molecular mechanisms controlling differentiation and function of osteoblasts is one o...