PURPOSE: Chemotherapy induced peripheral neuropathy (CIPN) is a debilitating condition that is a direct consequence of receiving cancer treatment. The molecular aetiology of CIPN is not well understood, and it is theorised that there may be a genetic component. Genetic polymorphisms in Glutathione-S Transferase (GST) genes, including GSTT1, GSTM1 and GSTP1, encode for enzymes known to metabolise drugs used in chemotherapy, and have been theorised to be associated with CIPN. This study aimed to investigate four markers in these genes for an association in a mixed cancer cohort in relation to CIPN (n = 172).METHODS: CIPN was measured using the neuropathy item from the Patient Reported Outcome Common Terminology Criteria for Adverse Event (PRO...
Objective: This work investigates the role of glutathione S-transferase M1 (GSTM1), glutathione S-tr...
Chemotherapy-induced peripheral neuropathy (CIPN) is an important clinical challenge that threatens ...
ObjectiveTaxane containing chemotherapy extends survival for breast cancer patients. However, taxane...
Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a common, disabling side effect in ...
Chemotherapy-induced peripheral neuropathy (CIPN) is a common dose-limiting toxicity experienced in ...
Background: Based on the possible shared mechanisms of chemotherapy-induced peripheral neuropathy (C...
Background: To assess the impact of polymorphisms in Glutathione S-transferase (GST) -P1, - M1, and ...
Chemotherapy-induced peripheral neuropathy (CIPN) is a common and debilitating condition associated ...
The association between glutathione-S-transferase P1 (GSTP1) Ile105Val polymorphism and oxaliplatin-...
<div><p></p><p><b>Background.</b> Docetaxel is a highly effective treatment of a wide range of malig...
Abstract Background Based on the possible shared mechanisms of chemotherapy-induced peripheral neuro...
Anticancer therapies are commonly prescribed for breast cancer and other solid tumors. While cytotox...
The aim of this study was to analyze whether polymorphisms for the null alleles of Glutathione S-Tra...
PurposeSensory peripheral neuropathy is a common and sometimes debilitating toxicity associated with...
OBJECTIVE: Taxane containing chemotherapy extends survival for breast cancer patients. However, taxa...
Objective: This work investigates the role of glutathione S-transferase M1 (GSTM1), glutathione S-tr...
Chemotherapy-induced peripheral neuropathy (CIPN) is an important clinical challenge that threatens ...
ObjectiveTaxane containing chemotherapy extends survival for breast cancer patients. However, taxane...
Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a common, disabling side effect in ...
Chemotherapy-induced peripheral neuropathy (CIPN) is a common dose-limiting toxicity experienced in ...
Background: Based on the possible shared mechanisms of chemotherapy-induced peripheral neuropathy (C...
Background: To assess the impact of polymorphisms in Glutathione S-transferase (GST) -P1, - M1, and ...
Chemotherapy-induced peripheral neuropathy (CIPN) is a common and debilitating condition associated ...
The association between glutathione-S-transferase P1 (GSTP1) Ile105Val polymorphism and oxaliplatin-...
<div><p></p><p><b>Background.</b> Docetaxel is a highly effective treatment of a wide range of malig...
Abstract Background Based on the possible shared mechanisms of chemotherapy-induced peripheral neuro...
Anticancer therapies are commonly prescribed for breast cancer and other solid tumors. While cytotox...
The aim of this study was to analyze whether polymorphisms for the null alleles of Glutathione S-Tra...
PurposeSensory peripheral neuropathy is a common and sometimes debilitating toxicity associated with...
OBJECTIVE: Taxane containing chemotherapy extends survival for breast cancer patients. However, taxa...
Objective: This work investigates the role of glutathione S-transferase M1 (GSTM1), glutathione S-tr...
Chemotherapy-induced peripheral neuropathy (CIPN) is an important clinical challenge that threatens ...
ObjectiveTaxane containing chemotherapy extends survival for breast cancer patients. However, taxane...