In a chiller plant, primary or critical sensors are used to control the system operation while secondary sensors are installed to monitor the performance/health of individual equipment. Current sensor fault detection and diagnosis (SFDD) approaches are not applicable to secondary sensors which usually are not involved in the system control. Consequently, a hybrid multiple sensor fault detection, diagnosis and reconstruction (HMSFDDR) algorithm for chiller plants was developed. Machine learning and pattern recognition were used to predict the primary sensor faults through the comparison of the weekly performance curves. With the primary sensor signals reconstructed, the secondary sensor faults were estimated based on mass and energy balance....