Add to ORKGWith the recent successes in determining membrane protein structures, we explore the tractability of determining representatives for the entire human membrane proteome. This proteome contains 2,925 unique integral α-helical transmembrane domain sequences that cluster into 1,201 families sharing more than 25% sequence identity. Structures of 100 optimally selected targets would increase the fraction of modelable human α-helical transmembrane domains from 26% to 58%, thus providing structure/function information not otherwise available
<div><p>Despite significant methodological advances in protein structure determination high-resoluti...
Cells require membrane proteins for a wide spectrum of critical functions. Transmembrane proteins en...
Availability of the human genome data has enabled the exploration of a huge amount of biological inf...
Given the recent successes in determining membrane-protein structures, we explore the tractability o...
Abstract: Transmembrane proteins allow cells to extensively communicate with the external world in a...
Background: Membrane proteins are key components in a large spectrum of diverse functions and thus a...
Membrane proteins serve as cellular gatekeepers, regulators, and sensors. Prior studies have explore...
Background: Transmembrane proteins have important roles in cells, as they are involved in energy pro...
Abstract Membrane proteins serve as cellular gatekeep-ers, regulators, and sensors. Prior studies ha...
Background A large proportion of an organism's genome encodes for membrane proteins. Membrane protei...
Availability of the human genome data has enabled the exploration of a huge amount of biological inf...
For current state-of-the-art methods, the prediction of correct topology of membrane proteins has be...
Structural information for biologically and medically interesting proteins can be difficult to obtai...
Abstract Background A large proportion of an organism's genome encodes for membrane proteins. Membra...
Membrane proteins comprise around 20-30% of a typical proteome and play crucial roles in a wide vari...
<div><p>Despite significant methodological advances in protein structure determination high-resoluti...
Cells require membrane proteins for a wide spectrum of critical functions. Transmembrane proteins en...
Availability of the human genome data has enabled the exploration of a huge amount of biological inf...
Given the recent successes in determining membrane-protein structures, we explore the tractability o...
Abstract: Transmembrane proteins allow cells to extensively communicate with the external world in a...
Background: Membrane proteins are key components in a large spectrum of diverse functions and thus a...
Membrane proteins serve as cellular gatekeepers, regulators, and sensors. Prior studies have explore...
Background: Transmembrane proteins have important roles in cells, as they are involved in energy pro...
Abstract Membrane proteins serve as cellular gatekeep-ers, regulators, and sensors. Prior studies ha...
Background A large proportion of an organism's genome encodes for membrane proteins. Membrane protei...
Availability of the human genome data has enabled the exploration of a huge amount of biological inf...
For current state-of-the-art methods, the prediction of correct topology of membrane proteins has be...
Structural information for biologically and medically interesting proteins can be difficult to obtai...
Abstract Background A large proportion of an organism's genome encodes for membrane proteins. Membra...
Membrane proteins comprise around 20-30% of a typical proteome and play crucial roles in a wide vari...
<div><p>Despite significant methodological advances in protein structure determination high-resoluti...
Cells require membrane proteins for a wide spectrum of critical functions. Transmembrane proteins en...
Availability of the human genome data has enabled the exploration of a huge amount of biological inf...