Add to ORKGHepcidin, the liver-produced peptide hormone, is a principal regulator of iron homeostasis. Abnormal hepcidin production has emerged as a causative factor in several common iron disorders. Hepcidin insufficiency results in iron overload in hereditary hemochromatosis and iron-loading anemias, whereas hepcidin excess causes or contributes to the development of iron-restricted anemias in inflammatory diseases, infections, some cancers and chronic kidney disease. Not surprisingly, hepcidin and related pathways have become the target for the development of novel therapeutics for iron disorders. In this review, we will summarize the strategies and development programs that have been devised for agonizing or antagonizing hepcidin and its receptor ...
The discovery of hepcidin has triggered a virtual explosion of studies on iron metabolism and relate...
The discovery of hepcidin has triggered a virtual explosion of studies on iron metabolism and relate...
Hepcidin, a peptide hormone produced by hepatocytes, is the central regulator of systemic iron homeo...
Inappropriate production of the iron-regulatory hormone hepcidin contributes to the pathogenesis of ...
The hepatic peptide hormone hepcidin regulates dietary iron absorption, plasma iron concentrations, ...
In vertebrates, hepcidin is the peptide hormone that homeostatically regulates the body's supply of ...
The interaction between hepcidin and ferroportin is the key mechanism involved in regulation of syst...
Hepcidin is a liver-synthesized hormone that inhibits the cellular efflux of iron by binding to ferr...
Iron is required for many biological processes but is also toxic in excess; thus, body iron balance ...
Iron is vital for bodily function but is potentially toxic and accordingly, tightly controlled in th...
Hepcidin is a key hormonal regulator of systemic iron homeostasis and its expression is induced by i...
The discovery of hepcidin clarified the basic mechanism of the control of systemic iron homeostasis....
AbstractDespite fluctuations in dietary iron intake and intermittent losses through bleeding, the pl...
Iron, an essential nutrient, is required for many diverse biological processes. The absence of a def...
Iron, an essential nutrient, is required for many diverse biological processes. The absence of a def...
The discovery of hepcidin has triggered a virtual explosion of studies on iron metabolism and relate...
The discovery of hepcidin has triggered a virtual explosion of studies on iron metabolism and relate...
Hepcidin, a peptide hormone produced by hepatocytes, is the central regulator of systemic iron homeo...
Inappropriate production of the iron-regulatory hormone hepcidin contributes to the pathogenesis of ...
The hepatic peptide hormone hepcidin regulates dietary iron absorption, plasma iron concentrations, ...
In vertebrates, hepcidin is the peptide hormone that homeostatically regulates the body's supply of ...
The interaction between hepcidin and ferroportin is the key mechanism involved in regulation of syst...
Hepcidin is a liver-synthesized hormone that inhibits the cellular efflux of iron by binding to ferr...
Iron is required for many biological processes but is also toxic in excess; thus, body iron balance ...
Iron is vital for bodily function but is potentially toxic and accordingly, tightly controlled in th...
Hepcidin is a key hormonal regulator of systemic iron homeostasis and its expression is induced by i...
The discovery of hepcidin clarified the basic mechanism of the control of systemic iron homeostasis....
AbstractDespite fluctuations in dietary iron intake and intermittent losses through bleeding, the pl...
Iron, an essential nutrient, is required for many diverse biological processes. The absence of a def...
Iron, an essential nutrient, is required for many diverse biological processes. The absence of a def...
The discovery of hepcidin has triggered a virtual explosion of studies on iron metabolism and relate...
The discovery of hepcidin has triggered a virtual explosion of studies on iron metabolism and relate...
Hepcidin, a peptide hormone produced by hepatocytes, is the central regulator of systemic iron homeo...