Add to ORKGInappropriate production of the iron-regulatory hormone hepcidin contributes to the pathogenesis of common iron disorders. Absolute or relative deficiency of hepcidin causes iron overload in hereditary hemochromatosis and iron-loading anemias. Elevated hepcidin causes iron restriction in inflammatory conditions including autoimmune disease, critical illness, some cancers, and chronic kidney disease. Multiple agents targeting hepcidin and its regulators are under development as novel therapeutics for iron disorders. This review summarizes hepcidin biology and discusses the current landscape for hepcidin-targeting therapeutic strategies
Iron, an essential nutrient, is required for many diverse biological processes. The absence of a def...
Iron, an essential nutrient, is required for many diverse biological processes. The absence of a def...
AbstractDespite fluctuations in dietary iron intake and intermittent losses through bleeding, the pl...
Hepcidin is a key hormonal regulator of systemic iron homeostasis and its expression is induced by i...
Hepcidin, the liver-produced peptide hormone, is a principal regulator of iron homeostasis. Abnormal...
The discovery of hepcidin has triggered a virtual explosion of studies on iron metabolism and relate...
The discovery of hepcidin has triggered a virtual explosion of studies on iron metabolism and relate...
Hepcidin is a liver-synthesized hormone that inhibits the cellular efflux of iron by binding to ferr...
In vertebrates, hepcidin is the peptide hormone that homeostatically regulates the body's supply of ...
Hepcidin, the iron-regulatory hormone, determines plasma iron concentrations and total body iron con...
Iron is vital for bodily function but is potentially toxic and accordingly, tightly controlled in th...
Hepcidin, a peptide hormone produced by hepatocytes, is the central regulator of systemic iron homeo...
Iron is required for many biological processes but is also toxic in excess; thus, body iron balance ...
The interaction between hepcidin and ferroportin is the key mechanism involved in regulation of syst...
International audienceAlthough iron is vital, its free form is likely to be involved in oxidation-re...
Iron, an essential nutrient, is required for many diverse biological processes. The absence of a def...
Iron, an essential nutrient, is required for many diverse biological processes. The absence of a def...
AbstractDespite fluctuations in dietary iron intake and intermittent losses through bleeding, the pl...
Hepcidin is a key hormonal regulator of systemic iron homeostasis and its expression is induced by i...
Hepcidin, the liver-produced peptide hormone, is a principal regulator of iron homeostasis. Abnormal...
The discovery of hepcidin has triggered a virtual explosion of studies on iron metabolism and relate...
The discovery of hepcidin has triggered a virtual explosion of studies on iron metabolism and relate...
Hepcidin is a liver-synthesized hormone that inhibits the cellular efflux of iron by binding to ferr...
In vertebrates, hepcidin is the peptide hormone that homeostatically regulates the body's supply of ...
Hepcidin, the iron-regulatory hormone, determines plasma iron concentrations and total body iron con...
Iron is vital for bodily function but is potentially toxic and accordingly, tightly controlled in th...
Hepcidin, a peptide hormone produced by hepatocytes, is the central regulator of systemic iron homeo...
Iron is required for many biological processes but is also toxic in excess; thus, body iron balance ...
The interaction between hepcidin and ferroportin is the key mechanism involved in regulation of syst...
International audienceAlthough iron is vital, its free form is likely to be involved in oxidation-re...
Iron, an essential nutrient, is required for many diverse biological processes. The absence of a def...
Iron, an essential nutrient, is required for many diverse biological processes. The absence of a def...
AbstractDespite fluctuations in dietary iron intake and intermittent losses through bleeding, the pl...