Sequence variants modulating gene function or expression affect various heritable traits, including the number of neurons within a population. The present study employed a forward-genetic approach to identify candidate causal genes and their sequence variants controlling the number of one type of retinal neuron, the AII amacrine cell. Data from twenty-six recombinant inbred (RI) strains of mice derived from the parental C57BL/6J (B6/J) and A/J laboratory strains were used to identify genomic loci regulating cell number. Large variation in cell number is present across the RI strains, from a low of ∼57,000 cells to a high of ∼87,000 cells. Quantitative trait locus (QTL) analysis revealed three prospective controlling genomic loci, on Chromos...
A fundamental challenge in genomics is to map DNA sequence variants onto changes in gene expression....
The study of complex genetic phenomena can be greatly facilitated by the use of model organisms. The...
PURPOSE: The present study defines genomic loci underlying coordinate changes in gene expression fol...
The mature retinal architecture is composed of various types of neuron, each population differing in...
Genetic variants modulate the numbers of various retinal cell types in mice. For instance, there is ...
Genetic variants modulate the numbers of various retinal cell types in mice. For instance, there is ...
Purpose—The size of neuronal populations is modulated by gene variants that influence cell productio...
<p>Genetic variants modulate the numbers of various retinal cell types in mice. For instance, there ...
<p>Genetic variants modulate the numbers of various retinal cell types in mice. For instance, there ...
Neuronal populations display conspicuous variability in their size among individuals, but the geneti...
The identification of genes that modify pathological ocular phenotypes in mouse models may improve o...
The central nervous system, is composed of several complex tissues that serve a wide variety of crit...
Variation in genetic background can significantly influence the phenotypic outcome of both disease a...
THESIS 7877There are many recorded examples in which genetic background has been shown to radically ...
SummaryThe sizes of different neuronal populations within the CNS are precisely controlled, but whet...
A fundamental challenge in genomics is to map DNA sequence variants onto changes in gene expression....
The study of complex genetic phenomena can be greatly facilitated by the use of model organisms. The...
PURPOSE: The present study defines genomic loci underlying coordinate changes in gene expression fol...
The mature retinal architecture is composed of various types of neuron, each population differing in...
Genetic variants modulate the numbers of various retinal cell types in mice. For instance, there is ...
Genetic variants modulate the numbers of various retinal cell types in mice. For instance, there is ...
Purpose—The size of neuronal populations is modulated by gene variants that influence cell productio...
<p>Genetic variants modulate the numbers of various retinal cell types in mice. For instance, there ...
<p>Genetic variants modulate the numbers of various retinal cell types in mice. For instance, there ...
Neuronal populations display conspicuous variability in their size among individuals, but the geneti...
The identification of genes that modify pathological ocular phenotypes in mouse models may improve o...
The central nervous system, is composed of several complex tissues that serve a wide variety of crit...
Variation in genetic background can significantly influence the phenotypic outcome of both disease a...
THESIS 7877There are many recorded examples in which genetic background has been shown to radically ...
SummaryThe sizes of different neuronal populations within the CNS are precisely controlled, but whet...
A fundamental challenge in genomics is to map DNA sequence variants onto changes in gene expression....
The study of complex genetic phenomena can be greatly facilitated by the use of model organisms. The...
PURPOSE: The present study defines genomic loci underlying coordinate changes in gene expression fol...