Add to ORKGThe spliceosome, an assembly of snRNAs and proteins, catalyzes the removal of introns from premessenger RNAs. A new study identifies specific phosphates in the U2-U6 snRNA complex that position two catalytic metals. Remarkably, these correspond precisely to metal-binding phosphates in a homologous structure of Group II self-splicing introns, long proposed to be the ribozyme progenitor of spliceosome
In the spliceosome, the pre-mRNA, U2 and U6 snRNAs fold into a catalytic structure exhibiting striki...
Pre-mRNA splicing occurs in two chemical steps that are catalyzed by a large, dynamic RNA-protein co...
Group II introns are naturally occurring ribozymes in plants, fungi, bacteria, and lower eukaryotes ...
The spliceosome, an assembly of snRNAs and proteins, catalyzes the removal of introns from premessen...
Spliceosomes are large, dynamic ribonucleoprotein complexes that catalyse the removal of introns fro...
In nuclear pre-messenger RNA splicing, introns are excised by the spliceosome, a multi-megadalton ma...
AbstractSince the discovery of self-splicing RNAs, it has been suspected that the snRNAs are the cat...
The spliceosome, the multi-megadalton molecular machine that performs splicing, consists of over 200...
The spliceosome is a large RNA‐protein complex that catalyses the removal of introns from nuclear pr...
SummaryGroup II introns are mobile genetic elements that have been implicated as agents of genetic d...
SummaryGroup II introns are self-splicing ribozymes that share a reaction mechanism and a common anc...
Eukaryotic genes contain non-coding introns, removal of which during gene expression is a pre-requis...
The spliceosome is formed on pre-mRNA substrates from five small nuclear ribonucleoprotein particles...
The intron–exon organization of the genes is nowadays taken for granted and constitutes a fully esta...
Group II introns are ribozymes occurring in genes of plants, fungi, lower eukaryotes, and bacteria. ...
In the spliceosome, the pre-mRNA, U2 and U6 snRNAs fold into a catalytic structure exhibiting striki...
Pre-mRNA splicing occurs in two chemical steps that are catalyzed by a large, dynamic RNA-protein co...
Group II introns are naturally occurring ribozymes in plants, fungi, bacteria, and lower eukaryotes ...
The spliceosome, an assembly of snRNAs and proteins, catalyzes the removal of introns from premessen...
Spliceosomes are large, dynamic ribonucleoprotein complexes that catalyse the removal of introns fro...
In nuclear pre-messenger RNA splicing, introns are excised by the spliceosome, a multi-megadalton ma...
AbstractSince the discovery of self-splicing RNAs, it has been suspected that the snRNAs are the cat...
The spliceosome, the multi-megadalton molecular machine that performs splicing, consists of over 200...
The spliceosome is a large RNA‐protein complex that catalyses the removal of introns from nuclear pr...
SummaryGroup II introns are mobile genetic elements that have been implicated as agents of genetic d...
SummaryGroup II introns are self-splicing ribozymes that share a reaction mechanism and a common anc...
Eukaryotic genes contain non-coding introns, removal of which during gene expression is a pre-requis...
The spliceosome is formed on pre-mRNA substrates from five small nuclear ribonucleoprotein particles...
The intron–exon organization of the genes is nowadays taken for granted and constitutes a fully esta...
Group II introns are ribozymes occurring in genes of plants, fungi, lower eukaryotes, and bacteria. ...
In the spliceosome, the pre-mRNA, U2 and U6 snRNAs fold into a catalytic structure exhibiting striki...
Pre-mRNA splicing occurs in two chemical steps that are catalyzed by a large, dynamic RNA-protein co...
Group II introns are naturally occurring ribozymes in plants, fungi, bacteria, and lower eukaryotes ...