Despite significant advances in our understanding of HIV, a cure has not been realized for the more than 34 million infected with this virus. HIV is incurable because infected individuals harbor cells where the HIV provirus is integrated into the host's DNA but is not actively replicating and thus is not inhibited by antiviral drugs. Similarly, these latent viruses are not detected by the immune system. In this Review, we discuss HIV-1 latency and the mechanisms that allow this pathogenic retrovirus to hide and persist by exploiting the cellular vehicles of immunological memory
The aim of this presentation is to review the molecular mechanisms necessary for the establishment o...
The infection of humans by human immunodeficiency virus type 1 is characterized by a prolonged stage...
Human immunodeficiency virus type 1 (HIV-1) persists as a lifelong infection, due to the establishme...
Despite significant advances in our understanding of HIV, a cure has not been realized for the more ...
Almost 30 years after its initial discovery, infection with the human immunodeficiency virus-1 (HIV-...
Almost 30 years after its initial discovery, infection with the human immunodeficiency virus-1 (HIV-...
In this thesis we focus on the ability of HIV-1 to establish a latent provirus in proliferating T ce...
The major obstacle towards HIV-1 eradication is the life-long persistence of the virus in reservoirs...
Abstract Latently infected cells represent the major barrier to either a sterilizing or a functional...
The use of combination antiretroviral therapy (ART) has resulted in a substantial reduction in virem...
International audienceCurrent therapies do not eradicate HIV from infected patients. Indeed, HIV hid...
Abstract Background Eradication of HIV-1 from an infected individual cannot be achieved by current d...
In a patient infected with HIV-1, the presence of latently infected cells from which the virus can b...
In a patient infected with HIV-1, the presence of latently infected cells from which the virus can b...
The introduction of highly active antiretroviral therapy (HAART) has been an important breakthrough ...
The aim of this presentation is to review the molecular mechanisms necessary for the establishment o...
The infection of humans by human immunodeficiency virus type 1 is characterized by a prolonged stage...
Human immunodeficiency virus type 1 (HIV-1) persists as a lifelong infection, due to the establishme...
Despite significant advances in our understanding of HIV, a cure has not been realized for the more ...
Almost 30 years after its initial discovery, infection with the human immunodeficiency virus-1 (HIV-...
Almost 30 years after its initial discovery, infection with the human immunodeficiency virus-1 (HIV-...
In this thesis we focus on the ability of HIV-1 to establish a latent provirus in proliferating T ce...
The major obstacle towards HIV-1 eradication is the life-long persistence of the virus in reservoirs...
Abstract Latently infected cells represent the major barrier to either a sterilizing or a functional...
The use of combination antiretroviral therapy (ART) has resulted in a substantial reduction in virem...
International audienceCurrent therapies do not eradicate HIV from infected patients. Indeed, HIV hid...
Abstract Background Eradication of HIV-1 from an infected individual cannot be achieved by current d...
In a patient infected with HIV-1, the presence of latently infected cells from which the virus can b...
In a patient infected with HIV-1, the presence of latently infected cells from which the virus can b...
The introduction of highly active antiretroviral therapy (HAART) has been an important breakthrough ...
The aim of this presentation is to review the molecular mechanisms necessary for the establishment o...
The infection of humans by human immunodeficiency virus type 1 is characterized by a prolonged stage...
Human immunodeficiency virus type 1 (HIV-1) persists as a lifelong infection, due to the establishme...