Our understanding of the genetic basis of disease has evolved from descriptions of overall heritability or familiality to the identification of large numbers of risk loci. One can quantify the impact of such loci on disease using a plethora of measures, which can guide future research decisions. However, different measures can attribute varying degrees of importance to a variant. In this Analysis, we consider and contrast the most commonly used measures - specifically, the heritability of disease liability, approximate heritability, sibling recurrence risk, overall genetic variance using a logarithmic relative risk scale, the area under the receiver-operating curve for risk prediction and the population attributable fraction - and give guid...
Candidate gene studies have become very popular but some of their implicit constraints, such as the ...
The recent large genotyping studies have identified a new repertoire of disease susceptibility loci ...
BackgroundThe prediction of the genetic disease risk of an individual is a powerful public health to...
Our understanding of the genetic basis of disease has evolved from descriptions of overall heritabil...
An increasing number of susceptibility genes have been identified for complex diseases in recent yea...
In most diseases of contemporary interest to epidemiology, the importance of familial risk factors i...
In most diseases of contemporary interest to epidemiology, the importance of familial risk factors i...
BACKGROUND: Evidence for genetic contribution to complex diseases is described by recurrence risks t...
Recently, an increasing number of susceptibility variants have been identified for complex diseases....
SummaryThe recurrence-risk ratio of disease in siblings, λS, is a standard parameter used in genetic...
Complex genetic diseases are defi ned as those infl uenced by multiple genes and by environmental ef...
Purpose: To develop a method of genetic risk categorization based on the risk conferred by genetic v...
The scientific debate following the initial formulation of the “bad luck” hypothesis in cancer devel...
Despite genetics being accepted as the primary cause of familial aggregation for most diseases, it i...
With increasing availability of polymorphic DNA markers, family studies can be used to identify link...
Candidate gene studies have become very popular but some of their implicit constraints, such as the ...
The recent large genotyping studies have identified a new repertoire of disease susceptibility loci ...
BackgroundThe prediction of the genetic disease risk of an individual is a powerful public health to...
Our understanding of the genetic basis of disease has evolved from descriptions of overall heritabil...
An increasing number of susceptibility genes have been identified for complex diseases in recent yea...
In most diseases of contemporary interest to epidemiology, the importance of familial risk factors i...
In most diseases of contemporary interest to epidemiology, the importance of familial risk factors i...
BACKGROUND: Evidence for genetic contribution to complex diseases is described by recurrence risks t...
Recently, an increasing number of susceptibility variants have been identified for complex diseases....
SummaryThe recurrence-risk ratio of disease in siblings, λS, is a standard parameter used in genetic...
Complex genetic diseases are defi ned as those infl uenced by multiple genes and by environmental ef...
Purpose: To develop a method of genetic risk categorization based on the risk conferred by genetic v...
The scientific debate following the initial formulation of the “bad luck” hypothesis in cancer devel...
Despite genetics being accepted as the primary cause of familial aggregation for most diseases, it i...
With increasing availability of polymorphic DNA markers, family studies can be used to identify link...
Candidate gene studies have become very popular but some of their implicit constraints, such as the ...
The recent large genotyping studies have identified a new repertoire of disease susceptibility loci ...
BackgroundThe prediction of the genetic disease risk of an individual is a powerful public health to...