PurposeStrategies to inhibit the EGF receptor (EGFR) using the tyrosine kinase inhibitor erlotinib have been associated with limited clinical efficacy in head and neck squamous cell carcinoma (HNSCC). Co-activation of alternative kinases may contribute to erlotinib resistance.Experimental designWe generated HNSCC cells expressing dominant-active c-Src (DA-Src) to determine the contribution of c-Src activation to erlotinib response.ResultsExpression of DA-Src conferred resistance to erlotinib in vitro and in vivo compared with vector-transfected control cells. Phospho-Met was strongly upregulated by DA-Src, and DA-Src cells did not produce hepatocyte growth factor (HGF). Knockdown of c-Met enhanced sensitivity to erlotinib in DA-Src cells in...
To study epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) resistance mechanisms...
The epidermal growth factor receptor (EGFR) is widely expressed in head and neck squamous cell carci...
c-Met, a high-affinity receptor for Hepatocyte Growth Factor (HGF), plays a critical role in tumor g...
Purpose: Strategies to inhibit the EGF receptor (EGFR) using the tyrosine kinase inhibitor erlotinib...
Keqiang Huang, Dongxu Liu Department of Orthodontics, School of Stomatology, Shandong University, S...
The proto-oncogene c-Src is a non-receptor tyrosine kinase playing a key role in many cellular pathw...
PurposeAcquired resistance to erlotinib in patients with EGFR-mutant non-small cell lung cancer can ...
Background The EGFR tyrosine kinase inhibitors gefitinib and erlotinib are first-line therapy for N...
BACKGROUND. EGFR and Src family kinases are upregulated in head and neck squamous cell carcinoma (HN...
<div><p>Tyrosine kinase inhibitors (TKIs) against EGFR and c-Met are initially effective when admini...
<div><p>The use of tyrosine kinase inhibitors (TKIs) against EGFR/c-Met in non-small cell lung cance...
BackgroundLung cancer is currently the second most prevalent form of cancer in the United States and...
The use of tyrosine kinase inhibitors (TKIs) against EGFR/c-Met in non-small cell lung cancer (NSCLC...
Resistance to the EGFR tyrosine kinase inhibitors (TKIs) gefitinib and erlotinib, often related to R...
The development of resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-T...
To study epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) resistance mechanisms...
The epidermal growth factor receptor (EGFR) is widely expressed in head and neck squamous cell carci...
c-Met, a high-affinity receptor for Hepatocyte Growth Factor (HGF), plays a critical role in tumor g...
Purpose: Strategies to inhibit the EGF receptor (EGFR) using the tyrosine kinase inhibitor erlotinib...
Keqiang Huang, Dongxu Liu Department of Orthodontics, School of Stomatology, Shandong University, S...
The proto-oncogene c-Src is a non-receptor tyrosine kinase playing a key role in many cellular pathw...
PurposeAcquired resistance to erlotinib in patients with EGFR-mutant non-small cell lung cancer can ...
Background The EGFR tyrosine kinase inhibitors gefitinib and erlotinib are first-line therapy for N...
BACKGROUND. EGFR and Src family kinases are upregulated in head and neck squamous cell carcinoma (HN...
<div><p>Tyrosine kinase inhibitors (TKIs) against EGFR and c-Met are initially effective when admini...
<div><p>The use of tyrosine kinase inhibitors (TKIs) against EGFR/c-Met in non-small cell lung cance...
BackgroundLung cancer is currently the second most prevalent form of cancer in the United States and...
The use of tyrosine kinase inhibitors (TKIs) against EGFR/c-Met in non-small cell lung cancer (NSCLC...
Resistance to the EGFR tyrosine kinase inhibitors (TKIs) gefitinib and erlotinib, often related to R...
The development of resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-T...
To study epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) resistance mechanisms...
The epidermal growth factor receptor (EGFR) is widely expressed in head and neck squamous cell carci...
c-Met, a high-affinity receptor for Hepatocyte Growth Factor (HGF), plays a critical role in tumor g...