In offspring exposed in utero to a maternal diet high in fat (HF), we have previously demonstrated that despite similar birth weights, HF adult offspring at 6 months of age had significantly higher body weights, greater adiposity, and increased triacylglycerol (TAG) levels as compared to controls. We hypothesized that a maternal HF diet predisposes to offspring adiposity via a programmed increase in the synthesis of monounsaturated fatty acids in the liver and hence increased substrate availability for liver TAG synthesis. We further hypothesized that programmed changes in offspring liver fatty acid metabolism are associated with increased liver expression of the lipogenic enzyme stearoyl-CoA desaturase-1 (SCD-1). Female rats were maintaine...
In utero exposure to maternal obesity increases the offspring's risk of obesity in later life. We ha...
The association between an adverse early life environment and increased susceptibility to later-life...
AbstractPoor prenatal nutrition, acting through epigenetic processes, induces persistent changes in ...
Excessive fat intake is a global health concern as women of childbearing age increasingly ingest hig...
Maternal high fat (HF) diet feeding is associated with increased risk of developing metabolism-relat...
High-fat (HF) and rapid digestive (RD) carbohydrate diets during pregnancy promote excessive adipoge...
The effects of maternal prenatal folic acid supplementation (FAS) on offspring lipid metabolism in a...
Linoleic acid (LA), an n-6 polyunsaturated fatty acid (PUFA), is essential for fetal growth and deve...
Abstract Background Small for gestational age (SGA) leads to increased risk of adult obesity and met...
International audienceNon-alcoholic fatty liver disease (NAFLD) has been described as a hepatic mani...
In utero exposure to maternal obesity increases the offspring’s risk of obesity in later life. We ha...
International audienceOBJECTIVE: The lactation-suckling period is critical for white adipose tissue ...
Fatty acid synthetase (FAS) expression and activity is controlled by nutritional and hormonal status...
International audienceAccording to the Developmental Origin of Health and Disease (DOHaD) concept, a...
Background: Although pregestational obesity has been associated with increased risk of adverse fetal...
In utero exposure to maternal obesity increases the offspring's risk of obesity in later life. We ha...
The association between an adverse early life environment and increased susceptibility to later-life...
AbstractPoor prenatal nutrition, acting through epigenetic processes, induces persistent changes in ...
Excessive fat intake is a global health concern as women of childbearing age increasingly ingest hig...
Maternal high fat (HF) diet feeding is associated with increased risk of developing metabolism-relat...
High-fat (HF) and rapid digestive (RD) carbohydrate diets during pregnancy promote excessive adipoge...
The effects of maternal prenatal folic acid supplementation (FAS) on offspring lipid metabolism in a...
Linoleic acid (LA), an n-6 polyunsaturated fatty acid (PUFA), is essential for fetal growth and deve...
Abstract Background Small for gestational age (SGA) leads to increased risk of adult obesity and met...
International audienceNon-alcoholic fatty liver disease (NAFLD) has been described as a hepatic mani...
In utero exposure to maternal obesity increases the offspring’s risk of obesity in later life. We ha...
International audienceOBJECTIVE: The lactation-suckling period is critical for white adipose tissue ...
Fatty acid synthetase (FAS) expression and activity is controlled by nutritional and hormonal status...
International audienceAccording to the Developmental Origin of Health and Disease (DOHaD) concept, a...
Background: Although pregestational obesity has been associated with increased risk of adverse fetal...
In utero exposure to maternal obesity increases the offspring's risk of obesity in later life. We ha...
The association between an adverse early life environment and increased susceptibility to later-life...
AbstractPoor prenatal nutrition, acting through epigenetic processes, induces persistent changes in ...