Add to ORKGIntroductionSince the 1980s, the primary treatment of acute Kawasaki disease (KD) has been intravenous immunoglobulin and aspirin. However, 5-10% of children with acute KD will develop coronary artery abnormalities despite treatment within the first ten days after fever onset. There is no approved adjunctive therapy to prevent progression of coronary artery damage in these patients.Areas coveredThe rationale and study design of a Phase I/IIa trial of atorvastatin in children with acute KD and coronary artery inflammation is presented. The studies of host genetics and KD pathogenesis leading up to this trial are reviewed.Expert opinionThe repurposing of well-studied drugs used in the adult population is a cost-effective and efficient strateg...
Background Kawasaki disease (KD) is a systemic syndrome of inflammatory with unknown cause...
Kawasaki disease (KD) is a medium vessel vasculitis and is the most common cause of acquired heart d...
Kawasaki disease (KD) is a childhood vasculitis syndrome and the coronary arteries are the main targ...
AbstractKawasaki disease (KD) is acute systemic vasculitis that occurs mainly in infants and childre...
OBJECTIVES: To determine the safety, tolerability, pharmacokinetics, and immunomodulatory effects of...
BackgroundAlthough Kawasaki disease (KD) is the most common cause of acquired heart disease in child...
ObjectivesTo determine the safety, tolerability, pharmacokinetics, and immunomodulatory effects of a...
Kawasaki disease (KD) is the most common cause of acquired heart disease in children in developed co...
Kawasaki disease (KD) has become the most common form of pediatric systemic vasculitis. Although pat...
Kawasaki disease (KD) is a self-limited childhood systemic vasculitis that exhibits a specific predi...
Kawasaki disease (KD) is an acute self-limiting systemic vasculitis of unknown aetiology. It is the ...
Kawasaki disease (KD) is an acute self-limiting inflammatory disorder, associated with vasculitis, a...
Abstract: Appropriate therapy during the acute phase of Kawasaki disease to prevent large coronary a...
Kawasaki syndrome is a potentially life-threatening disease of early childhood that untreated holds ...
Background: Kawasaki disease (KD) is an acute self-limiting inflammatory vasculitis affecting predom...
Background Kawasaki disease (KD) is a systemic syndrome of inflammatory with unknown cause...
Kawasaki disease (KD) is a medium vessel vasculitis and is the most common cause of acquired heart d...
Kawasaki disease (KD) is a childhood vasculitis syndrome and the coronary arteries are the main targ...
AbstractKawasaki disease (KD) is acute systemic vasculitis that occurs mainly in infants and childre...
OBJECTIVES: To determine the safety, tolerability, pharmacokinetics, and immunomodulatory effects of...
BackgroundAlthough Kawasaki disease (KD) is the most common cause of acquired heart disease in child...
ObjectivesTo determine the safety, tolerability, pharmacokinetics, and immunomodulatory effects of a...
Kawasaki disease (KD) is the most common cause of acquired heart disease in children in developed co...
Kawasaki disease (KD) has become the most common form of pediatric systemic vasculitis. Although pat...
Kawasaki disease (KD) is a self-limited childhood systemic vasculitis that exhibits a specific predi...
Kawasaki disease (KD) is an acute self-limiting systemic vasculitis of unknown aetiology. It is the ...
Kawasaki disease (KD) is an acute self-limiting inflammatory disorder, associated with vasculitis, a...
Abstract: Appropriate therapy during the acute phase of Kawasaki disease to prevent large coronary a...
Kawasaki syndrome is a potentially life-threatening disease of early childhood that untreated holds ...
Background: Kawasaki disease (KD) is an acute self-limiting inflammatory vasculitis affecting predom...
Background Kawasaki disease (KD) is a systemic syndrome of inflammatory with unknown cause...
Kawasaki disease (KD) is a medium vessel vasculitis and is the most common cause of acquired heart d...
Kawasaki disease (KD) is a childhood vasculitis syndrome and the coronary arteries are the main targ...