Add to ORKGWEE1 kinase regulates CDK1 and CDK2 activity to facilitate DNA replication during S-phase and to prevent unscheduled entry into mitosis. WEE1 inhibitors synergize with DNA-damaging agents that arrest cells in S-phase by triggering direct mitotic entry without completing DNA synthesis, resulting in catastrophic chromosome fragmentation and apoptosis. Here, we investigated how WEE1 inhibition could be best exploited for cancer therapy by performing a functional genetic screen to identify novel determinants of sensitivity to WEE1 inhibition. Inhibition of kinases that regulate CDK activity, CHK1 and MYT1, synergized with WEE1 inhibition through both increased replication stress and forced mitotic entry of S-phase cells. Loss of multiple compon...
The Wee1 cell cycle checkpoint kinase prevents premature mitotic entry by inhibiting cyclin-dependen...
The Wee1 cell cycle checkpoint kinase prevents premature mitotic entry by inhibiting cyclin-dependen...
During the cell cycle, DNA suffers several lesions that need to be repaired prior to entry into mito...
The Wee1 cell cycle checkpoint kinase prevents premature mitotic entry by inhibiting cyclin-dependen...
Cancer is defined by uncontrolled growth from irregular activity by cell cycle proteins; recently, s...
Cancer is defined by uncontrolled growth from irregular activity by cell cycle proteins; recently, s...
Cancer is defined by uncontrolled growth from irregular activity by cell cycle proteins; recently, s...
Inhibition of the protein kinase WEE1 synergizes with chemotherapy in preclinical models and WEE1 in...
In response to DNA breaks, the 'DNA damage response' provokes a cell cycle arrest to facilitate DNA ...
In response to DNA breaks, the 'DNA damage response' provokes a cell cycle arrest to facilitate DNA ...
In response to DNA breaks, the 'DNA damage response' provokes a cell cycle arrest to facilitate DNA ...
In response to DNA breaks, the 'DNA damage response' provokes a cell cycle arrest to facilitate DNA ...
WEE1 kinase is a key molecule in maintaining G₂-cell-cycle checkpoint arrest for premitotic DNA repa...
The Wee1 cell cycle checkpoint kinase prevents premature mitotic entry by inhibiting cyclin-dependen...
The Wee1 cell cycle checkpoint kinase prevents premature mitotic entry by inhibiting cyclin-dependen...
The Wee1 cell cycle checkpoint kinase prevents premature mitotic entry by inhibiting cyclin-dependen...
The Wee1 cell cycle checkpoint kinase prevents premature mitotic entry by inhibiting cyclin-dependen...
During the cell cycle, DNA suffers several lesions that need to be repaired prior to entry into mito...
The Wee1 cell cycle checkpoint kinase prevents premature mitotic entry by inhibiting cyclin-dependen...
Cancer is defined by uncontrolled growth from irregular activity by cell cycle proteins; recently, s...
Cancer is defined by uncontrolled growth from irregular activity by cell cycle proteins; recently, s...
Cancer is defined by uncontrolled growth from irregular activity by cell cycle proteins; recently, s...
Inhibition of the protein kinase WEE1 synergizes with chemotherapy in preclinical models and WEE1 in...
In response to DNA breaks, the 'DNA damage response' provokes a cell cycle arrest to facilitate DNA ...
In response to DNA breaks, the 'DNA damage response' provokes a cell cycle arrest to facilitate DNA ...
In response to DNA breaks, the 'DNA damage response' provokes a cell cycle arrest to facilitate DNA ...
In response to DNA breaks, the 'DNA damage response' provokes a cell cycle arrest to facilitate DNA ...
WEE1 kinase is a key molecule in maintaining G₂-cell-cycle checkpoint arrest for premitotic DNA repa...
The Wee1 cell cycle checkpoint kinase prevents premature mitotic entry by inhibiting cyclin-dependen...
The Wee1 cell cycle checkpoint kinase prevents premature mitotic entry by inhibiting cyclin-dependen...
The Wee1 cell cycle checkpoint kinase prevents premature mitotic entry by inhibiting cyclin-dependen...
The Wee1 cell cycle checkpoint kinase prevents premature mitotic entry by inhibiting cyclin-dependen...
During the cell cycle, DNA suffers several lesions that need to be repaired prior to entry into mito...