Add to ORKGIt is extremely rare for a single experiment to be so impactful and timely that it shapes and forecasts the experiments of the next decade. Here, we review how two such experiments-the generation of human induced pluripotent stem cells (iPSCs) and the development of CRISPR/Cas9 technology-have fundamentally reshaped our approach to biomedical research, stem cell biology, and human genetics. We will also highlight the previous knowledge that iPSC and CRISPR/Cas9 technologies were built on as this groundwork demonstrated the need for solutions and the benefits that these technologies provided and set the stage for their success
Human pluripotent stem cells (hPS cells) are rapidly emerging as a powerful tool for biomedical disc...
In the decade since Yamanaka and colleagues described methods to reprogram somatic cells into a plur...
The goal of editing the genomes of stem cells to generate model organisms and cell lines for genetic...
It is extremely rare for a single experiment to be so impactful and timely that it shapes and foreca...
According to current research, CRISPR/Cas9-mediated genome editing has shown enormous potential in t...
Cellular reprogramming by epigenomic remodeling of chromatin holds great promise in the field of hum...
Cellular reprogramming by epigenomic remodeling of chromatin holds great promise in the field of hum...
Cellular reprogramming by epigenomic remodeling of chromatin holds great promise in the field of hum...
Human-induced pluripotent stem cells (hiPSCs) and CRISPR/Cas9 gene editing system represent two inst...
Genome editing of human pluripotent stem cells (hPSCs) with the CRISPR/Cas9 system has the potential...
Directing the fates of human pluripotent stem cells (hPSC) to generate a multitude of differentiated...
Induced pluripotent stem cells (iPSCs) originate from the reprogramming of adult somatic cells using...
Genome-editing involves the insertion, deletion, or replacement of DNA in the genome of a living org...
Embryonic stem cells (ESCs) are chiefly characterized by their ability to self-renew and to differen...
Genetic manipulation is a powerful tool to establish the causal relationship between a genetic lesio...
Human pluripotent stem cells (hPS cells) are rapidly emerging as a powerful tool for biomedical disc...
In the decade since Yamanaka and colleagues described methods to reprogram somatic cells into a plur...
The goal of editing the genomes of stem cells to generate model organisms and cell lines for genetic...
It is extremely rare for a single experiment to be so impactful and timely that it shapes and foreca...
According to current research, CRISPR/Cas9-mediated genome editing has shown enormous potential in t...
Cellular reprogramming by epigenomic remodeling of chromatin holds great promise in the field of hum...
Cellular reprogramming by epigenomic remodeling of chromatin holds great promise in the field of hum...
Cellular reprogramming by epigenomic remodeling of chromatin holds great promise in the field of hum...
Human-induced pluripotent stem cells (hiPSCs) and CRISPR/Cas9 gene editing system represent two inst...
Genome editing of human pluripotent stem cells (hPSCs) with the CRISPR/Cas9 system has the potential...
Directing the fates of human pluripotent stem cells (hPSC) to generate a multitude of differentiated...
Induced pluripotent stem cells (iPSCs) originate from the reprogramming of adult somatic cells using...
Genome-editing involves the insertion, deletion, or replacement of DNA in the genome of a living org...
Embryonic stem cells (ESCs) are chiefly characterized by their ability to self-renew and to differen...
Genetic manipulation is a powerful tool to establish the causal relationship between a genetic lesio...
Human pluripotent stem cells (hPS cells) are rapidly emerging as a powerful tool for biomedical disc...
In the decade since Yamanaka and colleagues described methods to reprogram somatic cells into a plur...
The goal of editing the genomes of stem cells to generate model organisms and cell lines for genetic...