Add to ORKGImmune surveillance should be directed to suppress tumor development and progression, involving a balance of coinhibitory and costimulatory signals that amplify immune response without overwhelming the host. Immunotherapy confers durable clinical benefit in 'immunogenic tumors', whereas in other tumors the responses are modest. Thus, immune checkpoint inhibitors may need to be combined with strategies to boost immune response or increase the tumor immune profile. Epigenetic aberrations contribute significantly to carcinogenesis. Recent findings suggest that epigenetic drugs prime the immune response by increasing expression of tumor-associated antigens and immune-related genes, as well as modulating chemokines and cytokines involved in immu...
Checkpoint inhibitor therapy constitutes a promising cancer treatment strategy that targets the immu...
In 2018, the Nobel Prize in medicine was awarded to James P. Allison and Tasuku Honjo for their work...
Abstract Immune checkpoint factors, such as programmed cell death protein-1/2 (PD-1, PD-2) or cytoto...
Continuously improving knowledge of the fine mechanisms regulating cross-talk between immune cells, ...
Recently, immunotherapeutic approaches have shown impressive responses in a subset of cancer patient...
Epigenetic mechanisms are processes that affect gene expression and cellular functions without invol...
The efficacy of cancer immunotherapy relies on the ability of the host immune system to recognise th...
Epigenetic alterations play a pivotal role in cancer development and progression. Pharmacologic reve...
Immunotherapy has brought new hope for cancer patients in recent times. However, despite the promisi...
A balance between co-inhibitory and co-stimulatory signals in the tumor microenvironment (TME) is cr...
Cancer cells are under the surveillance of the host immune system. Nevertheless, a number of immunos...
The efficacy of cancer immunotherapy relies on the ability of the host immune system to recognise th...
Altres ajuts: This work was supported by the the Cellex Foundation; and La Caixa Banking Foundation ...
Epigenetic regulation allows heritably modulating gene expression profiles without modifying the pri...
A balance between co-inhibitory and co-stimulatory signals in the tumor microenvironment (TME) is cr...
Checkpoint inhibitor therapy constitutes a promising cancer treatment strategy that targets the immu...
In 2018, the Nobel Prize in medicine was awarded to James P. Allison and Tasuku Honjo for their work...
Abstract Immune checkpoint factors, such as programmed cell death protein-1/2 (PD-1, PD-2) or cytoto...
Continuously improving knowledge of the fine mechanisms regulating cross-talk between immune cells, ...
Recently, immunotherapeutic approaches have shown impressive responses in a subset of cancer patient...
Epigenetic mechanisms are processes that affect gene expression and cellular functions without invol...
The efficacy of cancer immunotherapy relies on the ability of the host immune system to recognise th...
Epigenetic alterations play a pivotal role in cancer development and progression. Pharmacologic reve...
Immunotherapy has brought new hope for cancer patients in recent times. However, despite the promisi...
A balance between co-inhibitory and co-stimulatory signals in the tumor microenvironment (TME) is cr...
Cancer cells are under the surveillance of the host immune system. Nevertheless, a number of immunos...
The efficacy of cancer immunotherapy relies on the ability of the host immune system to recognise th...
Altres ajuts: This work was supported by the the Cellex Foundation; and La Caixa Banking Foundation ...
Epigenetic regulation allows heritably modulating gene expression profiles without modifying the pri...
A balance between co-inhibitory and co-stimulatory signals in the tumor microenvironment (TME) is cr...
Checkpoint inhibitor therapy constitutes a promising cancer treatment strategy that targets the immu...
In 2018, the Nobel Prize in medicine was awarded to James P. Allison and Tasuku Honjo for their work...
Abstract Immune checkpoint factors, such as programmed cell death protein-1/2 (PD-1, PD-2) or cytoto...