Add to ORKG7,20-Diisocyanoadociane, a scarce marine metabolite with potent antimalarial activity, was synthesized as a single enantiomer in 13 steps from simple building blocks (17 linear steps). Chemical synthesis enabled identification of isocyanoterpene antiplasmodial activity against liver-stage parasites, which suggested that inhibition of heme detoxification does not exclusively underlie the mechanism of action of this class
Malaria is a lethal disease responsible for human deaths numbering hundreds of thousands every year....
Callophycolide A is a meroditerpene isolated from Callophycus serratus, a Fijian red macroalgae. Cal...
Since their discovery in the 1970s, the striking architectures and the unusual isonitrile functional...
7,20-Diisocyanoadociane, a scarce marine metabolite with potent antimalarial activity, was synthesiz...
A formal total synthesis of diisocyanoadociane, a marine diterpenoid with potent antimalarial proper...
The flagship member of the antiplasmodial isocyanoterpenes, 7,20-diisocyanoadociane (DICA), was synt...
A full account of the development of a concise and highly stereoselective synthesis of (+)-7,20-diis...
7-Isocyano-11(20),14-epiamphilectadiene, the most potent of antimalarial amphilectenes, is synthesi...
Total synthesis and methodology are two large fields of study in synthetic organic chemistry which s...
Three new isocyanoditerpenes (5-7) have been characterized from Australian specimens of the nudibran...
Three new isocyanoditerpenes (<b>5</b>–<b>7</b>) have been characterized from Australian specimens o...
An anionic oxy-Cope/transannular conjugate addition approach to the potent antimalarial 7,20-diisocy...
Of the 50+ kalihinane diterpenoids reported to date, only five had been tested for antimalarial acti...
Of the 50+ kalihinane diterpenoids reported to date, only five had been tested for antimalarial acti...
Of the 50+ kalihinane diterpenoids reported to date, only five had been tested for antimalarial acti...
Malaria is a lethal disease responsible for human deaths numbering hundreds of thousands every year....
Callophycolide A is a meroditerpene isolated from Callophycus serratus, a Fijian red macroalgae. Cal...
Since their discovery in the 1970s, the striking architectures and the unusual isonitrile functional...
7,20-Diisocyanoadociane, a scarce marine metabolite with potent antimalarial activity, was synthesiz...
A formal total synthesis of diisocyanoadociane, a marine diterpenoid with potent antimalarial proper...
The flagship member of the antiplasmodial isocyanoterpenes, 7,20-diisocyanoadociane (DICA), was synt...
A full account of the development of a concise and highly stereoselective synthesis of (+)-7,20-diis...
7-Isocyano-11(20),14-epiamphilectadiene, the most potent of antimalarial amphilectenes, is synthesi...
Total synthesis and methodology are two large fields of study in synthetic organic chemistry which s...
Three new isocyanoditerpenes (5-7) have been characterized from Australian specimens of the nudibran...
Three new isocyanoditerpenes (<b>5</b>–<b>7</b>) have been characterized from Australian specimens o...
An anionic oxy-Cope/transannular conjugate addition approach to the potent antimalarial 7,20-diisocy...
Of the 50+ kalihinane diterpenoids reported to date, only five had been tested for antimalarial acti...
Of the 50+ kalihinane diterpenoids reported to date, only five had been tested for antimalarial acti...
Of the 50+ kalihinane diterpenoids reported to date, only five had been tested for antimalarial acti...
Malaria is a lethal disease responsible for human deaths numbering hundreds of thousands every year....
Callophycolide A is a meroditerpene isolated from Callophycus serratus, a Fijian red macroalgae. Cal...
Since their discovery in the 1970s, the striking architectures and the unusual isonitrile functional...