International audienceHepaRG cells are highly-differentiated human hepatoma cells, which are increasingly recognized as a convenient cellular model for in vitro evaluation of hepatic metabolism, transport and/or toxicity of drugs. The present study was designed to evaluate whether HepaRG cells can also be useful for studying drug-mediated inhibition of canalicular and/or sinusoidal hepatic efflux of bile acids, which constitutes a major mechanism of drug-induced liver toxicity (DILI). For this purpose, HepaRG cells, initially loaded with the bile acid taurocholate (TC), were re-incubated in TC-free transport assay medium, in the presence or absence of calcium or drugs, before analysis of TC retention. This method allowed to objectivise and ...
International audienceThe role of hepatobiliary transporters in drug-induced liver injury remains po...
International audienceIntrahepatic cholestasis represents 20%-40%of drug-induced injuries from which...
International audienceThe role of hepatobiliary transporters in drug-induced liver injury remains po...
International audienceHepaRG cells are highly-differentiated human hepatoma cells, which are increas...
International audienceHepaRG cells are highly-differentiated human hepatoma cells, which are increas...
International audienceA dynamic model based on ordinary differential equations that describes uptake...
International audienceA dynamic model based on ordinary differential equations that describes uptake...
International audienceA dynamic model based on ordinary differential equations that describes uptake...
International audienceA dynamic model based on ordinary differential equations that describes uptake...
International audienceSince HepaRG cells can differentiate into well-polarized mature hepatocyte-lik...
International audienceSince HepaRG cells can differentiate into well-polarized mature hepatocyte-lik...
Intrahepatic bile acid accumulation due to inhibition of the bile salt export pump (BSEP) has been p...
International audienceMany drugs have been reported to induce cholestasis in a dose-dependent or ind...
Hepatocellular accumulation of bile acids due to inhibition of the canalicular bile salt export pump...
Hepatocellular accumulation of bile acids due to inhibition of the canalicular bile salt export pump...
International audienceThe role of hepatobiliary transporters in drug-induced liver injury remains po...
International audienceIntrahepatic cholestasis represents 20%-40%of drug-induced injuries from which...
International audienceThe role of hepatobiliary transporters in drug-induced liver injury remains po...
International audienceHepaRG cells are highly-differentiated human hepatoma cells, which are increas...
International audienceHepaRG cells are highly-differentiated human hepatoma cells, which are increas...
International audienceA dynamic model based on ordinary differential equations that describes uptake...
International audienceA dynamic model based on ordinary differential equations that describes uptake...
International audienceA dynamic model based on ordinary differential equations that describes uptake...
International audienceA dynamic model based on ordinary differential equations that describes uptake...
International audienceSince HepaRG cells can differentiate into well-polarized mature hepatocyte-lik...
International audienceSince HepaRG cells can differentiate into well-polarized mature hepatocyte-lik...
Intrahepatic bile acid accumulation due to inhibition of the bile salt export pump (BSEP) has been p...
International audienceMany drugs have been reported to induce cholestasis in a dose-dependent or ind...
Hepatocellular accumulation of bile acids due to inhibition of the canalicular bile salt export pump...
Hepatocellular accumulation of bile acids due to inhibition of the canalicular bile salt export pump...
International audienceThe role of hepatobiliary transporters in drug-induced liver injury remains po...
International audienceIntrahepatic cholestasis represents 20%-40%of drug-induced injuries from which...
International audienceThe role of hepatobiliary transporters in drug-induced liver injury remains po...