The Wonderland of Our Genomes

Genomic medicine is the branch of modern medicine that uses genetic and genomic information to develop personalized strategies for patient care, disease prevention, and treatment. It involves the study of an individual's genetic information to understand the underlying causes of disease and to develop personalized healthcare interventions. Surprisingly, the genetic information that determines an individual’s risk of diseases comes not only from the human genome but also from the gut microbiome, which is the collective genomes of the microorganisms residing in the human gut.The release of the complete sequence of the human genome in 2003 and the completion of the first phase of the human gut microbiome project in 2013 opened up a new horizon for human genomics research. Just as in Alice’s Wonderland, this led to many amazing discoveries, but there are still many unknowns. This lecture shares my vision of which ways we ought to go to improve our understanding of host–microbe interactions in human health and disease