Our lungs are exposed daily to airborne pollutants, particulate matter, pathogens as well as lung allergens and irritants. Exposure to these substances can lead to inflammatory responses and may induce endogenous oxidant production, which can cause chronic inflammation, tissue damage and remodeling. Notably, the development of asthma and Chronic Obstructive Pulmonary Disease (COPD) is linked to the aforementioned irritants. Some inhaled foreign chemical compounds are rapidly absorbed and processed by phase I and II enzyme systems critical in the detoxification of xenobiotics including the glutathione-conjugating enzymes Glutathione S-transferases (GSTs). GSTs, and in particular genetic variants of GSTs that alter their activities, have been...
Asthma is defined as a heterogeneous pulmonary disease, characterized by chronic inflammation, which...
Oxidant-mediated tissue injury is key to the pathogenesis of acute lung injury. Glutathione-S-transf...
Background: Interleukin-1-dependent increases in glycolysis promote allergic airways disease in mice...
Our lungs are exposed daily to airborne pollutants, particulate matter, pathogens as well as lung al...
Our lungs are exposed daily to airborne pollutants, particulate matter, pathogens as well as lung al...
Background: Glutathione-S-Transferase (GST) family of enzymes serve as a key antioxidant system. Cli...
The origins of respiratory disease, such as asthma in childhood and COPD in later life are unclear. ...
Abstract Background Oxidative stress plays a potential role in the pathogenesis and progression of c...
Background: Glutathione-S-Transferase (GST) family of enzymes serve as a key antioxidant system. Cli...
Lung inflammation resulting from oxidant/antioxidant imbalance is a common feature of many lung dise...
Genome wide association (GWA) studies have reproducibly identified signals on chromosome 4q24 associ...
Abstract Background The major contribution to oxidant related lung damage in COPD is from the oxidan...
Asthma is defined as a heterogeneous pulmonary disease, characterized by chronic inflammation, which...
Oxidant-mediated tissue injury is key to the pathogenesis of acute lung injury. Glutathione-S-transf...
Background: Interleukin-1-dependent increases in glycolysis promote allergic airways disease in mice...
Our lungs are exposed daily to airborne pollutants, particulate matter, pathogens as well as lung al...
Our lungs are exposed daily to airborne pollutants, particulate matter, pathogens as well as lung al...
Background: Glutathione-S-Transferase (GST) family of enzymes serve as a key antioxidant system. Cli...
The origins of respiratory disease, such as asthma in childhood and COPD in later life are unclear. ...
Abstract Background Oxidative stress plays a potential role in the pathogenesis and progression of c...
Background: Glutathione-S-Transferase (GST) family of enzymes serve as a key antioxidant system. Cli...
Lung inflammation resulting from oxidant/antioxidant imbalance is a common feature of many lung dise...
Genome wide association (GWA) studies have reproducibly identified signals on chromosome 4q24 associ...
Abstract Background The major contribution to oxidant related lung damage in COPD is from the oxidan...
Asthma is defined as a heterogeneous pulmonary disease, characterized by chronic inflammation, which...
Oxidant-mediated tissue injury is key to the pathogenesis of acute lung injury. Glutathione-S-transf...
Background: Interleukin-1-dependent increases in glycolysis promote allergic airways disease in mice...