Gene fusions constitute pivotal driver mutations often encoding aberrant chimeric transcription factors. However, an increasing number of gene fusion events have been shown not to be histotype specific and shared among different tumor types, otherwise completely unrelated clinically or phenotypically. One such remarkable example of chromosomal translocation promiscuity is represented by fusions between EWSR1 or FUS with genes encoding for CREB-transcription factors family (ATF1, CREB1, and CREM), driving the pathogenesis of various tumor types spanning mesenchymal, neuroectodermal, and epithelial lineages. In this study, we investigate a group of 13 previously unclassified malignant epithelioid neoplasms, frequently showing an epithelial im...
EWSR1 belongs to the FET family of RNA-binding proteins including also Fused in Sarcoma (FUS), and T...
Clear cell odontogenic carcinoma (CCOC) is a rare, low-grade malignant epithelial neoplasm, occurrin...
Clear cell odontogenic carcinoma (CCOC) is a rare, low-grade malignant epithelial neoplasm, occurrin...
Gene fusions constitute pivotal driver mutations often encoding aberrant chimeric transcription fact...
Sclerosing epithelioid fibrosarcoma (SEF) is a rare, malignant fibroblastic neoplasm, morphologicall...
About a third of soft tissue tumors are recognized by gene fusions. Some of these fusions are not hi...
Myoepithelial (ME) tumors of soft tissue and bone display a heterogeneous histologic spectrum and in...
Mesenchymal round cell tumors are a diverse group of neoplasms defined by primitive, often high-grad...
Abstract Background Clear cell sarcoma of soft tissue (CCSST) and clear cell sarcoma-like gastrointe...
The present thesis concerns the involvement of EWSR1 and FUS fusion genes, and the chimeric proteins...
Angiomatoid fibrous histiocytoma (AFH) is a rare soft tissue tumor that usually occurs in children a...
Fusions of the EWSR1 gene with partners from the CREB gene family have been identified in several hi...
Low-grade fibromyxoid sarcoma (LGFMS) is an indolent, late-metastasizing malignant soft-tissue tumor...
Intracranial mesenchymal tumors with FET-CREB fusions are a recently described group of neoplasms in...
The Intraabdominal Desmoplastic Small Round Cell Tumor (IADSRCT) is a pediatric/adolescent tumor bel...
EWSR1 belongs to the FET family of RNA-binding proteins including also Fused in Sarcoma (FUS), and T...
Clear cell odontogenic carcinoma (CCOC) is a rare, low-grade malignant epithelial neoplasm, occurrin...
Clear cell odontogenic carcinoma (CCOC) is a rare, low-grade malignant epithelial neoplasm, occurrin...
Gene fusions constitute pivotal driver mutations often encoding aberrant chimeric transcription fact...
Sclerosing epithelioid fibrosarcoma (SEF) is a rare, malignant fibroblastic neoplasm, morphologicall...
About a third of soft tissue tumors are recognized by gene fusions. Some of these fusions are not hi...
Myoepithelial (ME) tumors of soft tissue and bone display a heterogeneous histologic spectrum and in...
Mesenchymal round cell tumors are a diverse group of neoplasms defined by primitive, often high-grad...
Abstract Background Clear cell sarcoma of soft tissue (CCSST) and clear cell sarcoma-like gastrointe...
The present thesis concerns the involvement of EWSR1 and FUS fusion genes, and the chimeric proteins...
Angiomatoid fibrous histiocytoma (AFH) is a rare soft tissue tumor that usually occurs in children a...
Fusions of the EWSR1 gene with partners from the CREB gene family have been identified in several hi...
Low-grade fibromyxoid sarcoma (LGFMS) is an indolent, late-metastasizing malignant soft-tissue tumor...
Intracranial mesenchymal tumors with FET-CREB fusions are a recently described group of neoplasms in...
The Intraabdominal Desmoplastic Small Round Cell Tumor (IADSRCT) is a pediatric/adolescent tumor bel...
EWSR1 belongs to the FET family of RNA-binding proteins including also Fused in Sarcoma (FUS), and T...
Clear cell odontogenic carcinoma (CCOC) is a rare, low-grade malignant epithelial neoplasm, occurrin...
Clear cell odontogenic carcinoma (CCOC) is a rare, low-grade malignant epithelial neoplasm, occurrin...