BACKGROUND: The common cytotoxic mechanisms that underpin chemoefficacy and toxicity have hampered efforts to deliver effective supportive care interventions, particularly for gastrointestinal (GI) toxicity. Matrix metalloproteinases (MMPs) have been implicated in both tumor growth and GI toxicity, and as such MMP inhibitors present as a novel therapeutic avenue to simultaneously enhance treatment efficacy and reduce toxicity.OBJECTIVES: The aim of this study was to determine the efficacy of an MMP-9/12 inhibitor, AZD3342, on tumor growth and GI toxicity in a rat model.METHODS: Female tumor-bearing Dark Agouti rats (n = 90) were divided into 4 groups: vehicle control; methotrexate (MTX); AZD3342, and MTX + AZD3342. Tumors were measured dail...
金沢大学医薬保健研究域薬学系Purpose: Methotrexate (MTX) causes dose-limiting gastrointestinal toxicity due to expo...
Expression of matrix metalloproteinase 9 (MMP9) is elevated in a variety of inflammatory and oncolog...
Introduction: Irinotecan is a common chemotherapeutic agent that's use is associated with severe gas...
BACKGROUND: The common cytotoxic mechanisms that underpin chemoefficacy and toxicity have hampered e...
BACKGROUND:The common cytotoxic mechanisms that underpin chemoefficacy and toxicity have hampered ef...
Purpose: The implication of matrix metalloproteinases (MMPs) in the major stages of cancer progressi...
CONTEXT: Chemotherapeutic agents such as methotrexate (MTX) are commonly used in the treatment of ca...
This item is only available electronically.Thesis (BHlthMSc(Hons)) -- University of Adelaide, Adelai...
Purpose: Combination of COL-3, a matrix metalloproteinase inhibitor, and doxorubicin (DOX) might be ...
Gastrointestinal mucositis is a serious side effect of chemotherapy. Currently, no effective treatme...
Gelatinase B or matrix metalloproteinase-9 (MMP-9) (EC 3.4.24.35) is increased in inflammatory proce...
α-Sulfone-α-piperidine and α-tetrahydropyranyl hydroxamates were explored that are potent inhibitors...
OBJECTIVES: Gastrointestinal (GI) mucositis is a severe side effect of chemotherapy and radiotherapy...
金沢大学医薬保健研究域薬学系Purpose: Methotrexate (MTX) causes dose-limiting gastrointestinal toxicity due to expo...
<div><p>Expression of matrix metalloproteinase 9 (MMP9) is elevated in a variety of inflammatory and...
金沢大学医薬保健研究域薬学系Purpose: Methotrexate (MTX) causes dose-limiting gastrointestinal toxicity due to expo...
Expression of matrix metalloproteinase 9 (MMP9) is elevated in a variety of inflammatory and oncolog...
Introduction: Irinotecan is a common chemotherapeutic agent that's use is associated with severe gas...
BACKGROUND: The common cytotoxic mechanisms that underpin chemoefficacy and toxicity have hampered e...
BACKGROUND:The common cytotoxic mechanisms that underpin chemoefficacy and toxicity have hampered ef...
Purpose: The implication of matrix metalloproteinases (MMPs) in the major stages of cancer progressi...
CONTEXT: Chemotherapeutic agents such as methotrexate (MTX) are commonly used in the treatment of ca...
This item is only available electronically.Thesis (BHlthMSc(Hons)) -- University of Adelaide, Adelai...
Purpose: Combination of COL-3, a matrix metalloproteinase inhibitor, and doxorubicin (DOX) might be ...
Gastrointestinal mucositis is a serious side effect of chemotherapy. Currently, no effective treatme...
Gelatinase B or matrix metalloproteinase-9 (MMP-9) (EC 3.4.24.35) is increased in inflammatory proce...
α-Sulfone-α-piperidine and α-tetrahydropyranyl hydroxamates were explored that are potent inhibitors...
OBJECTIVES: Gastrointestinal (GI) mucositis is a severe side effect of chemotherapy and radiotherapy...
金沢大学医薬保健研究域薬学系Purpose: Methotrexate (MTX) causes dose-limiting gastrointestinal toxicity due to expo...
<div><p>Expression of matrix metalloproteinase 9 (MMP9) is elevated in a variety of inflammatory and...
金沢大学医薬保健研究域薬学系Purpose: Methotrexate (MTX) causes dose-limiting gastrointestinal toxicity due to expo...
Expression of matrix metalloproteinase 9 (MMP9) is elevated in a variety of inflammatory and oncolog...
Introduction: Irinotecan is a common chemotherapeutic agent that's use is associated with severe gas...