Recently, the copper toxicosis (CT) locus in Bedlington terriers was assigned to canine chromosome region CFA10q26, which is homologous to human chromosome region HSA2p13-21. A comparative map between CFA10q21-26 and HSA2p13-21 was constructed by using genes already localized to HSA2p13-21. A high-resolution radiation map of CFA10q21-26 was constructed to facilitate positional cloning of the CT gene. For this map, seven Type I and eleven Type II markers were mapped. Using homozygosity mapping, the CT locus could be confined to a 42.3 cR(3000) region, between the FH2523 and C10.602 markers. On the basis of a partial BAC contig, it was estimated that 1-cR(3000) is equivalent to approximately 210 kb, implying that the CT candidate region is th...
BACKGROUND: Non-Wilsonian hepatic copper toxicosis includes Indian childhood cirrhosis (ICC), endemi...
Copper toxicosis is a complex genetic disorder in Labrador retrievers characterized by hepatic coppe...
Linkage disequilibrium (LD) mapping is commonly used as a fine mapping tool in human genome mapping ...
Recently, the copper toxicosis (CT) locus in Bedlington terriers was assigned to canine chromosome r...
Positional cloning recently identified the mutation causing copper toxicosis (CT) in Bedlington terr...
Copper toxicosis (CT) is a common autosomal recessive disorder in dogs. Recently, the CT locus was c...
Objective-To evaluate the haplotype distribution associated with the copper toxicosis gene and the s...
Recently, linkage of a DNA microsatellite marker to inherited copper toxicosis has been reported in ...
The One Health principle recognizes that human health, animal health, and environmental health are i...
Funder: UK Bedlington Terrier AssociationBACKGROUND: Bedlington terrier copper toxicosis (CT) is due...
BACKGROUND: Non-Wilsonian hepatic copper toxicosis includes Indian childhood cirrhosis (ICC), endemi...
Copper toxicosis is a complex genetic disorder in Labrador retrievers characterized by hepatic coppe...
Linkage disequilibrium (LD) mapping is commonly used as a fine mapping tool in human genome mapping ...
Recently, the copper toxicosis (CT) locus in Bedlington terriers was assigned to canine chromosome r...
Positional cloning recently identified the mutation causing copper toxicosis (CT) in Bedlington terr...
Copper toxicosis (CT) is a common autosomal recessive disorder in dogs. Recently, the CT locus was c...
Objective-To evaluate the haplotype distribution associated with the copper toxicosis gene and the s...
Recently, linkage of a DNA microsatellite marker to inherited copper toxicosis has been reported in ...
The One Health principle recognizes that human health, animal health, and environmental health are i...
Funder: UK Bedlington Terrier AssociationBACKGROUND: Bedlington terrier copper toxicosis (CT) is due...
BACKGROUND: Non-Wilsonian hepatic copper toxicosis includes Indian childhood cirrhosis (ICC), endemi...
Copper toxicosis is a complex genetic disorder in Labrador retrievers characterized by hepatic coppe...
Linkage disequilibrium (LD) mapping is commonly used as a fine mapping tool in human genome mapping ...