Nature-inspired molecules containing multiple electrophilic positions:Synthesis and application as activity-based probes and inhibitors

The research in this thesis shows that enol carbamates react with hyper-reactive cysteine and serine residues within proteins. By equipping the scaffold with a reporter group, chemical probes can be obtained that label enzyme containing these residues. The reactivity of the scaffold can be tuned to increase the potency and to generate selectivity for proteins of interest